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Regulatory T Cell Development.

Annual Review of Immunology, 2020
Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of
P. Savage, D. E. Klawon, Christine H. Miller   +2 more
semanticscholar   +3 more sources

Regulatory T cell memory [PDF]

Nature Reviews Immunology, 2015
Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime ...
M. Rosenblum, S. Way, A. Abbas
semanticscholar   +5 more sources

Regulatory T cell therapy for xenotransplantation, what perspectives? [PDF]

Frontiers in Immunology
Xenotransplantation has experienced major clinical advancements over the past three years. Yet, despite potent immunosuppressive regimens combining B-cell depleting therapies, T cell activation blockade, complement inhibition, and high-dose steroids ...
Raphaël Porret, Erica Lana, Antonio Mancarella, Philippe Guillaume, Manuel Pascual, Raphael P. H. Meier, Jonathan S. Bromberg, Muhammad M. Mohiuddin, Leo H. Buhler, Qizhi Tang, Qizhi Tang, Yannick D. Muller   +11 more
doaj   +2 more sources

Metabolic Pathways Involved in Regulatory T Cell Functionality

Frontiers in Immunology, 2019
Regulatory T cells (Treg) are well-known for their immune regulatory potential and are essential for maintaining immune homeostasis. The rationale of Treg-based immunotherapy for treating autoimmunity and transplant rejection is to tip the immune balance
Rosalie W. M. Kempkes, Irma Joosten, Hans J. P. M. Koenen, Xuehui He   +3 more
doaj   +2 more sources

Regulatory T Cells [PDF]

Journal of Investigative Dermatology, 2006
Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described.
Beissert, Stefan, Schwarz, Agatha, Schwarz, Thomas   +2 more
  +6 more sources

Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation

Frontiers in Immunology, 2021
Regulatory T cells (Tregs) constitute a small proportion of circulating CD4+ T cells that function to maintain homeostasis and prevent autoimmunity. In light of their powerful immunosuppressive and tolerance-promoting properties, Tregs have become an ...
Caroline Dudreuilh, Caroline Dudreuilh, Caroline Dudreuilh, Sumoyee Basu, Sumoyee Basu, Sumoyee Basu, Cristiano Scottà, Cristiano Scottà, Cristiano Scottà, Anthony Dorling, Anthony Dorling, Anthony Dorling, Giovanna Lombardi, Giovanna Lombardi, Giovanna Lombardi   +14 more
doaj   +1 more source

Regulatory T cell ablation causes acute T cell lymphopenia. [PDF]

PLoS ONE, 2014
Regulatory T (Treg) cells enforce T cell homeostasis and maintain peripheral T cell tolerance. Here we report a previously unappreciated phenomenon of acute T cell lymphopenia in secondary lymphoid organs and non-lymphoid tissues triggered by Treg cell ...
Bruno Moltedo, Saskia Hemmers, Alexander Y Rudensky   +2 more
doaj   +1 more source

Transforming growth factor–β1 in regulatory T cell biology

Science immunology, 2022
Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg) biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and function is complicated by the pleiotropic and context-dependent activity of ...
J. Moreau, Maria Velegraki, Chelsea M Bolyard, M. Rosenblum, Zihai Li   +4 more
semanticscholar   +1 more source

Tissue regulatory T cells [PDF]

Immunology, 2020
SummaryFoxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic and anti‐self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially.
Prudence PokWai Lui, Inchul Cho, Niwa Ali   +2 more
openaire   +2 more sources

Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]

Open Biology, 2013
Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes, Victoria S. Pelly, Mark S. Wilson   +2 more
doaj   +1 more source