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Regulating regulatory T cells [PDF]

Bone Marrow Transplantation, 2006
Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress activation of other immune cells and thereby maintain immune system homeostasis, self-tolerance as well as control excessive response to foreign antigens. The mere concept of Tregs was the subject of significant controversy among immunologists for many years ...
N T, Le, N, Chao
openaire   +2 more sources

Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development. [PDF]

PLoS ONE, 2015
T cells reactive to microbiota regulate the pathogenesis of inflammatory bowel disease (IBD). As T cell trafficking to intestines is regulated through interactions between highly specific chemokine-chemokine receptors, efforts have been made to develop ...
Heather L Evans-Marin, Anthony T Cao, Suxia Yao, Feidi Chen, Chong He, Han Liu, Wei Wu, Maria G Gonzalez, Sara M Dann, Yingzi Cong   +9 more
doaj   +1 more source

Regulatory T cell function in autoimmune disease

Journal of Translational Autoimmunity, 2021
Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance.
Anandi Rajendeeran, Klaus Tenbrock
doaj   +1 more source

CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures

Frontiers in Immunology, 2018
Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g ...
Anna Nowak, Dominik Lock, Petra Bacher, Thordis Hohnstein, Katrin Vogt, Judith Gottfreund, Pascal Giehr, Julia K. Polansky, Birgit Sawitzki, Andrew Kaiser, Jörn Walter, Alexander Scheffold, Alexander Scheffold   +12 more
doaj   +1 more source

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions

Frontiers in Cell and Developmental Biology, 2022
B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan, Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K James, Niels Olsen Saraiva Camara, S.M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Quan Gong, Zheng Liu, Chaohong Liu   +17 more
doaj   +1 more source

High glucose promotes regulatory T cell differentiation.

PLoS ONE, 2023
The consumption of processed foods and sugary sodas in Western diets correlates with an increased incidence of obesity, metabolic syndromes such as type 2 diabetes, cardiovascular diseases, and autoimmune diseases including inflammatory bowel disease and
Elise Pitmon, Eileen Victoria Meehan, Elham Ahmadi, Adam J Adler, Kepeng Wang   +4 more
doaj   +1 more source

T regulatory cells [PDF]

Current Biology, 2005
First discovered… The existence of T regulatory cells was first suggested by several animal models in the 1970s. Organ-specific autoimmunity was found to be induced in specific strains of mice that had been thymectomized 3 days after birth but not after thymectomy at 0 or 7 days.
openaire   +2 more sources

Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans

Frontiers in Immunology, 2018
Background: Regulatory T (Treg) cells are necessary for the maintenance of allogenic pregnancy. However, the repertoire of effector Treg cells at the feto-maternal interface in human pregnancy remains unknown.
Sayaka Tsuda, Xiaoxin Zhang, Hiroshi Hamana, Tomoko Shima, Akemi Ushijima, Kei Tsuda, Atsushi Muraguchi, Hiroyuki Kishi, Shigeru Saito   +8 more
doaj   +1 more source

Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer

Frontiers in Immunology, 2021
The intestinal immune system has the difficult task of protecting a large environmentally exposed single layer of epithelium from pathogens without allowing inappropriate inflammatory responses.
Daniel DiToro, Daniel DiToro, Daniel DiToro, Rajatava Basu   +3 more
doaj   +1 more source

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

Cell Reports Medicine, 2021
Summary: Immune suppression by CD4+FOXP3+ regulatory T (Treg) cells and tumor infiltration by CD8+ effector T cells represent two major factors impacting response to cancer immunotherapy.
Jaime L. Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V. Ozerov, Matthew T. Walker, Kathleen Higgins, Mark W. Lingen, Evgeny Izumchenko, Peter A. Savage   +8 more
doaj   +1 more source