Results 11 to 20 of about 1,279,789 (265)
The relativity of regulatory T cell suppression modes [PDF]
Frontiers in ImmunologyFoxp3-expressing CD4 regulatory T (Treg) cells are essential for maintaining immune tolerance through antigen-specific and bystander suppression modes.
Lu Bai, Vivek Choudhary, Yongqiang Feng
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Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) constitute a small proportion of circulating CD4+ T cells that function to maintain homeostasis and prevent autoimmunity. In light of their powerful immunosuppressive and tolerance-promoting properties, Tregs have become an ...
Caroline Dudreuilh +14 more
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Regulatory T cell ablation causes acute T cell lymphopenia. [PDF]
PLoS ONE, 2014 Regulatory T (Treg) cells enforce T cell homeostasis and maintain peripheral T cell tolerance. Here we report a previously unappreciated phenomenon of acute T cell lymphopenia in secondary lymphoid organs and non-lymphoid tissues triggered by Treg cell ...
Bruno Moltedo +2 more
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Journal of Investigative Dermatology, 2006 Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described.
Beissert, Stefan +2 more
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Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]
Open Biology, 2013 Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes +2 more
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Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets
Frontiers in Immunology, 2023 IntroductionChronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell dysregulation within the adaptive immune system that has yet to be fully characterized ...
Cameron W. Paterson +7 more
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Nanodrugs Targeting T Cells in Tumor Therapy
Frontiers in Immunology, 2022 In contrast to conventional anti-tumor agents, nano-carriers allow co-delivery of distinct drugs in a cell type-specific manner. So far, many nanodrug-based immunotherapeutic approaches aim to target and kill tumor cells directly or to address antigen ...
Maximilian Haist +2 more
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Regulatory T Cells as Immunotherapy [PDF]
Frontiers in Immunology, 2014 Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy.
Singer, Benjamin D. +2 more
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Tissue regulatory T cells [PDF]
Immunology, 2020 SummaryFoxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic and anti‐self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially.
Prudence PokWai Lui +2 more
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Regulatory T Cell Metabolism in Atherosclerosis
Metabolites, 2020 Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a ...
Jeroen Baardman, Esther Lutgens
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