Results 11 to 20 of about 1,257,811 (269)
Analysis of the transcriptional program of developing induced regulatory T cells. [PDF]
, 2011 CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). To gain insight into the mechanisms governing iTreg development, we performed
Lipsky, Peter E. +8 more
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Regulatory T Cells in Autoimmmunity [PDF]
Annual Review of Immunology, 2000 Clonal deletion of autoreactive T cells in the thymus is not the sole mechanism for the induction of tolerance to self-antigens since partial depletion of peripheral CD4+T cells from neonatal and adult animals results in the development of organ-specific autoimmunity.
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Regulatory T cells and vasectomy [PDF]
Journal of Reproductive Immunology, 2013 CD4+ CD25+ regulatory T cells (Tregs) strongly influence the early and late autoimmune responses to meiotic germ cell antigens (MGCA) and the gonadal immunopathology in vasectomized mice. This is supported by the published and recently acquired information presented here.
Claudia, Rival +11 more
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Role of regulatory T cells in immune tolerance [PDF]
, 2009 In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
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Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
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Metabolic regulation of regulatory T cell development and function
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Marelli-Berg, F +7 more
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Regulatory immune cells in transplantation. [PDF]
, 2012 Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew +9 more
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, 2005 CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J +19 more
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Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]
, 2011 The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J. +28 more
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Regulatory T Cells in Atherogenesis
Journal of Atherosclerosis and Thrombosis, 2012 Atherosclerosis is believed to be an inflammatory condition of the arterial wall. It has become apparent that various types of cells of innate and adaptive immunity participate in atherogenesis. T cells are of particular interest because they mediate pathogenic immune responses involved in the acceleration of atherosclerosis.
Sasaki, Naoto +3 more
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