Results 91 to 100 of about 2,996,073 (354)

Regulatory T Cell Metabolism in the Hepatic Microenvironment

Frontiers in Immunology, 2018
Thymic-derived naturally occurring regulatory T cells (tTreg) are crucial for maintaining peripheral immune homeostasis. They play a crucial role in preventing autoimmunity and maintaining organ transplant without requiring immunosuppression.
Rebecca Ellen Wawman, Rebecca Ellen Wawman, Helen Bartlett, Ye Htun Oo, Ye Htun Oo   +4 more
doaj   +1 more source

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

Journal of Experimental Medicine, 2014
CD44loCD62Lhi regulatory T cells preferentially access IL-2 in T cell zones due to expression of ...
Kate S. Smigiel, Elizabeth Richards, S. Srivastava, Kerri R. Thomas, J. Dudda, K. Klonowski, D. Campbell   +6 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Concomitant use of interleukin-2 and tacrolimus suppresses follicular helper T cell proportion and exerts therapeutic effect against lupus nephritis in systemic lupus erythematosus-like chronic graft versus host disease

Frontiers in Immunology
IntroductionDefective interleukin-2 (IL-2) production contributes to immune system imbalance in patients with systemic erythematosus lupus (SLE). Recent clinical studies suggested that low-dose IL-2 treatment is beneficial for SLE and the therapeutic ...
Yutaro Nasa, Atsushi Satake, Ryohei Tsuji, Ryo Saito, Yukie Tsubokura, Hideaki Yoshimura, Tomoki Ito   +6 more
doaj   +1 more source

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

Nature Immunology, 2015
The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen–specific maternal CD4+ T cells during pregnancy.
Lokesh A. Kalekar, Shirdi E Schmiel, Sarada L Nandiwada, Wing Y Lam, Laura O Barsness, N. Zhang, Gretta L. Stritesky, D. Malhotra, Kristen E. Pauken, Jonathan L. Linehan, M. O’Sullivan, B. Fife, K. Hogquist, M. Jenkins, D. Mueller   +14 more
semanticscholar   +1 more source

Low doses of CMV induce autoimmune-mediated and inflammatory responses in bile duct epithelia of regulatory T cell-depleted neonatal mice [PDF]

, 2014
Jie Wen, Yongtao Xiao, Jun Wang, Weihua Pan, Minghao Yin, Xiaoling Zhang, Wenbin Guan, Yingwei Chen, Kejun Zhou, Yang Wang, Bisheng Shi, Xiaohui Zhou, Zhenghong Yuan, Wei Cai   +13 more
openalex   +1 more source

Supplementary Figure 2 from Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

, 2023
Ping‐Ying Pan, Ge Ma, Kaare J. Weber, Junko Ozao‐Choy, George Wang, Bingjiao Yin, Celia M. Divino, Shu‐Hsia Chen   +7 more
openalex   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Regulatory T cells

Biology of Blood and Marrow Transplantation, 2005
Blazar, Bruce R., Taylor, Patricia A.
  +6 more sources

T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function

Cell Reports
Summary: While cGAS is known as a cytosolic DNA sensor in innate immunity, its function in T cells and adaptive immunity remains uncharacterized. This study investigates the role of cGAS in regulatory T (Treg) cells.
Hongpeng Li, Yuchen Zhang, Shangze Gao, Hang Yin   +3 more
doaj   +1 more source