Results 71 to 80 of about 1,257,811 (269)

Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells [PDF]

, 2007
Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens
Owain R Millington, Bernd H. Zinselmeyer, Zinselmeyer Bernd H, Brewer James M, Paul Garside, Rush, Catherine M., Rush, C.M., Owain R. Millington, Millington, O.R., Vivienne B Gibson, Catherine M. Rush, Bernd H Zinselmeyer, Rush, C., R. Stephen Phillips, Gibson, V.B., Vivienne B. Gibson, Phillips, R.S., R Stephen Phillips, Catherine M Rush, Zinselmeyer, B.H., Millington, Owain R., Brewer, James M., Gibson Vivienne B, Millington Owain R, Brewer, J.M., Gibson, Vivienne B., Phillips R. Stephen, Garside Paul, Rush Catherine M, Phillips, R. Stephen, Zinselmeyer, Bernd H., Garside, P., James M. Brewer, Garside, Paul, James M Brewer   +34 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Constraints on the CD8 T cell response in chronic HBV infection [PDF]

, 2009
The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting.
Das, A., Das, A
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Editorial: Regulatory T Cells

Frontiers in Cell and Developmental Biology, 2022
Issa, F, Gu, J, Lu, L
openaire   +3 more sources

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. [PDF]

, 2014
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Susanne MA van der Pol, Male, David K, Cerutti, Camilla, Michael, G.J., Dongsheng Wu, van der Pol, SM, Sharrack, B, Romero, I.A., Baker, D., Michael, Gregory J, Simpson, Julie E., Cerutti, C., Simpson, J.E., Lopez-Ramirez, Miguel A., David Baker, Romero, IA, Wu, D.S., de Vries, H.E., Baker, David, King-Robson, J., Basil Sharrack, Simpson, Julie E, Michael, GJ, Wu, Dongsheng, van der Pol, Susanne M A, Hirst, Mark C, Julie E Simpson, Ignacio A Romero, Pryce, Gareth, Baker, D, Gregory J Michael, de Vries, Helga E, Romero, Ignacio A., Hirst, MC, King-Robson, Josh, de Vries, HE, Lopez-Ramirez, Alejandro, Mark C Hirst, David K Male, Male, DK, de Vries, Helga E., Gareth Pryce, Josh King-Robson, Camilla Cerutti, van der Pol, SMA, Romero, Ignacio A, van der Pol, S.M.A., Lopez-Ramirez, Miguel A, Male, D.K., Male, David K., Sharrack, B., King-Robson, J, van der Pol, Susanne M. A., Wu, D, Simpson, JE, Lopez-Ramirez, MA, Miguel A Lopez-Ramirez, Hirst, M.C., van der Pol, Susanne Ma, Cerutti, C, Helga E de Vries, Pryce, G, Pryce, G., Hirst, Mark C., Sharrack, Basil, Michael, Gregory J., Lopez-Ramirez, M.A.   +66 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Hunter, Christopher A, Couper, Kevin N, Riley, Eleanor M, Greig, Rachel, Blount, Daniel G, Blount, Daniel G., Stumhofer, Jason S, Hafalla, Julius CR, De Souza, J. Brian, Findlay, Emily Gwyer, Shaw, Tovah N, de Souza, J Brian, Riley, Eleanor M., Shaw, Tovah N., Stumhofer, Jason S., Hunter, Christopher A., Hafalla, Julius C R, Couper, Kevin N., Gwyer Findlay, Emily, Villegas-Mendez, Ana   +19 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source