Results 121 to 130 of about 2,996,073 (354)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases [PDF]

, 2017
Jason S. Ellis, Helen Braley‐Mullen
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Science, 2007
D. Mucida, Yunji Park, Gisen Kim, O. Turovskaya, Iain Scott, M. Kronenberg, H. Cheroutre   +6 more
semanticscholar   +1 more source

Data from CEACAM1 Marks Highly Suppressive Intratumoral Regulatory T Cells for Targeted Depletion Therapy

, 2023
Seung Hyuck Jeon, Minyong Kang, Minwoo Jeon, Youseung Chung, A Reum Kim, Yong Joon Lee, Eui-Soon Kim, Heejin Nam, Junsik Park, Jung‐Yun Lee, Eui‐Cheol Shin, Seong Il Seo, Su‐Hyung Park   +12 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Nature, 2019
Xinyang Song, XiMei Sun, Sungwhan F. Oh, Meng Wu, Yanbo Zhang, Wen Zheng, N. Geva-Zatorsky, R. Jupp, D. Mathis, C. Benoist, Dennis L. Kasper   +10 more
semanticscholar   +1 more source

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

, 2015
Bernard Khor, John D Gagnon, Gautam Goel, Marly I. Roche, Kara L. Conway, Khoa Tran, Leslie N. Aldrich, Thomas B. Sundberg, Alison M. Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H. Tan, Atul K. Bhan, Rahul Roychoudhuri, Nicholas P. Restifo, John J. O’Shea, Benjamin D. Medoff, Alykhan F. Shamji, Stuart L. Schreiber, Arlene H. Sharpe, Stanley Y. Shaw, Ramnik J. Xavier   +22 more
openalex   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Uncovering regulatory B‐cell features associated with regulatory T‐cell expansion and global T‐cell exhaustion in Waldenström macroglobulinemia Myd88L252P‐like lymphoplasmacytic lymphomas

HemaSphere
Waldenström's macroglobulinemia (WM) is a rare, indolent lymphoproliferative disorder, genetically characterized by the presence of the L265P mutation in the MYD88 gene in almost all cases, resulting in constitutive activation of NF‐kappa B (NF‐κB ...
Quentin Lemasson, Maxime Tabaud, Ophélie Téteau, Bastien Carle, Mina Chabaud, Jean Feuillard, Nathalie Faumont, Christelle Vincent‐Fabert   +7 more
doaj   +1 more source