Results 31 to 40 of about 1,958,413 (325)

Transcript-indexed ATAC-seq for precision immune profiling. [PDF]

, 2018
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D, Chang, Howard Y, Corces, M Ryan, Davis, Mark M, Gennert, David G, Granja, Jeffrey M, Greenleaf, William J, Khavari, Paul A, Khodadoust, Michael S, Kim, Youn H, Lareau, Caleb A, Li, Rui, Mumbach, Maxwell R, Parker, Kevin R, Qi, Yanyan, Rubin, Adam J, Saligrama, Naresha, Satpathy, Ansuman T, Schep, Alicia N, Serratelli, William S, Wei, Yuning, Wu, Beijing   +21 more
core   +1 more source

In vitro Regulatory T cells Differentiation From Naïve T Cells

Bio-Protocol, 2014
In the past years, a subset of regulatory T cells (Tregs) expressing CD4, CD25 and the transcription factor FoxP3 has gained considerable attention as key regulators of T-cell tolerance and homeostasis (Sakaguchi, 2004).
Tomas Dalotto , Gabriel Rabinovich, Marian Salatino   +2 more
doaj   +1 more source

Regulatory T cells in retroviral infections. [PDF]

PLoS Pathogens, 2018
Tight regulation of immune responses is not only critical for preventing autoimmune diseases but also for preventing immunopathological damage during infections in which overactive immune responses may be more harmful for the host than the pathogen ...
Kim J Hasenkrug, Claire A Chougnet, Ulf Dittmer   +2 more
doaj   +1 more source

Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. [PDF]

, 2008
Different functions have been attributed to natural regulatory CD4+CD25+FOXP+ (Treg) cells during malaria infection. Herein, we assessed the role for Treg cells during infections with lethal (DS) and non-lethal (DK) Plasmodium chabaudi adami parasites ...
Belanger, B, Cambos, M, Jacques, A, Roulet, A, Scorza, T   +4 more
core   +1 more source

Regulatory T cells in paracoccidioidomycosis

Virulence, 2019
This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen.
Vera L. G. Calich, Ronei L. Mamoni, Flávio V. Loures   +2 more
doaj   +1 more source

Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased T_reg CD25 Expression and Reduced Frequency of Effector T_reg Subpopulation

Cells, 2021
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by immune cell infiltration of the synovium, leading to the loss of cartilage, bone, and joint function.
Eunbyeol Go, Su-Jin Yoo, Suyoung Choi, Pureum Sun, Min Kyung Jung, Somin Kwon, Bu Yeon Heo, Yeeun Kim, Ju-Gyeong Kang, Jinhyun Kim, Eui-Cheol Shin, Seong Wook Kang, Jaeyul Kwon   +12 more
doaj   +1 more source

CD4+ regulatory T cells

Current Opinion in Immunology, 2001
There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
openaire   +3 more sources

REGULATORY T–CELLS: ORIGIN AND FUNCTION

Медицинская иммунология, 2014
. Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification ...
I. S. Freidlin
doaj   +1 more source

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

Cell Reports, 2018
Summary: Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease mediated by the interplay of T cells and polymorphonuclear granulocytes. Although preclinical studies have provided insights into the mechanisms of disease
Tom Hartwig, Pascale Zwicky, Bettina Schreiner, Nikhil Yawalkar, Phil Cheng, Alexander Navarini, Reinhard Dummer, Lukas Flatz, Curdin Conrad, Christoph Schlapbach, Burkhard Becher   +10 more
doaj   +1 more source

Notch/Delta signaling constrains reengineering of pro-T cells by PU.1 [PDF]

, 2006
PU.1 is essential for early stages of mouse T cell development but antagonizes it if expressed constitutively. Two separable mechanisms are involved: attenuation and diversion. Dysregulated PU.1 expression inhibits pro-T cell survival, proliferation, and
Adams, Stephanie L., Diamond, Rochelle A., Franco, Christopher B., Proekt, Irina, Rothenberg, Ellen V., Scripture-Adams, Dierdre D., Taghon, Tom, Weiss, Angela H., Yui, Mary A.   +8 more
core   +3 more sources