Results 31 to 40 of about 304,002 (266)
Regulatory T Cells in Autoimmmunity [PDF]
Annual Review of Immunology, 2000 Clonal deletion of autoreactive T cells in the thymus is not the sole mechanism for the induction of tolerance to self-antigens since partial depletion of peripheral CD4+T cells from neonatal and adult animals results in the development of organ-specific autoimmunity.
openaire +4 more sources
Regulatory T cell memory [PDF]
Nature Reviews Immunology, 2015 Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime ...
Rosenblum, Michael D +2 more
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Cells, 2021 Rheumatoid arthritis (RA) is a common autoimmune disease characterized by immune cell infiltration of the synovium, leading to the loss of cartilage, bone, and joint function.
Eunbyeol Go +12 more
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Regulatory T Cells and Parasites [PDF]
BioMed Research International, 2011 Human host encounters a wide array of parasites; however, the crucial aspect is the failure of the host immune system to clear these parasites despite antigen recognition. In the recent past, a new immunological concept has emerged, which provides a framework to better understand several aspects of host susceptibility to parasitic infection.
Olusola Ojurongbe +1 more
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Graphical Models for Zero-Inflated Single Cell Gene Expression [PDF]
Ann. Appl. Stat., Volume 13, Number 2 (2019), 848-873, 2016 Bulk gene expression experiments relied on aggregations of thousands of cells to measure the average expression in an organism. Advances in microfluidic and droplet sequencing now permit expression profiling in single cells. This study of cell-to-cell variation reveals that individual cells lack detectable expression of transcripts that appear abundant
arxiv +1 more source
REGULATORY T–CELLS: ORIGIN AND FUNCTION
Медицинская иммунология, 2014 . Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification ...
I. S. Freidlin
doaj +1 more source
Dynamical and Structural Modularity of Discrete Regulatory Networks [PDF]
EPTCS 6, 2009, pp. 109-124, 2009 A biological regulatory network can be modeled as a discrete function that contains all available information on network component interactions. From this function we can derive a graph representation of the network structure as well as of the dynamics of the system.
arxiv +1 more source
Persistent immune activation in CVID and the role of IVIg in its suppression
Frontiers in Immunology, 2014 Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as ...
Dominic ePaquin-Proulx +1 more
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Plasticity of human CD4 T cell subsets
Frontiers in Immunology, 2014 Human beings are exposed to a variety of different pathogens, which induce tailored immune responses and consequently generate highly diverse populations of pathogen-specific T cells.
Jens eGeginat +8 more
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T follicular helper cells and T follicular regulatory cells in autoimmune diseases
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
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