Results 81 to 90 of about 1,141,931 (248)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Supplementary Data from IFNα Augments Clinical Efficacy of Regulatory T-cell Depletion with Denileukin Diftitox in Ovarian Cancer

, 2023
Suzanne R. Thibodeaux, Brian B. Barnett, Srilakshmi Pandeswara, Shawna R. Wall, Vincent Hurez, Vinh Dao, Lishi Sun, Benjamin J. Daniel, Michael J. Brumlik, Justin Drerup, Álvaro Padrón, Teresa Whiteside, Ilona Kryczek, Weiping Zou, Tyler J. Curiel   +14 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Anti-regulatory T cells are natural regulatory effector T cells

Cell Stress, 2019
Niels Ødum
doaj   +1 more source

Supplementary Figure 3 from Reducing TNF Receptor 2⁺ Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients

, 2023
Chindu Govindaraj, Peter Tan, Patricia Walker, Andrew H. Wei, Andrew Spencer, Magdalena Plebanski   +5 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Rapamycin added to human CD25+ cell cultures activated through CD3/CD28 enriches for CD4+CD25+CD27+Foxp3+ regulatory T cells [PDF]

, 2006
Carolyn A. Keever-Taylor, M.B. Browning, Bryon D. Johnson, R L Truitt, B. Behn   +4 more
openalex   +1 more source

Supplementary Figure S2 from Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity

, 2023
Rachel Perret, Sophie Sierro, Natalia K. Botelho, Stéphanie Corgnac, Alena Donda, Pedro Romero   +5 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Microbiota activation and regulation of adaptive immunity

Frontiers in Immunology
In the mucosa, T cells and B cells of the immune system are essential for maintaining immune homeostasis by suppressing reactions to harmless antigens and upholding the integrity of intestinal mucosal barrier functions.
Mozhdeh Heidari, Saman Maleki Vareki, Saman Maleki Vareki, Saman Maleki Vareki, Ramin Yaghobi, Mohammad Hossein Karimi   +5 more
doaj   +1 more source