Results 101 to 110 of about 1,033,187 (394)

Discrete and continuum models for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes and tumour cells [PDF]

arXiv, 2021
We present an individual-based model for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes (CTLs) and tumour cells. In this model, every cell is viewed as an individual agent whose phenotypic state is modelled by a discrete variable. For tumour cells this variable represents a parameterisation of the antigen expression profiles, while ...
arxiv  

CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation [PDF]

Seminars in Immunology, 2006
Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens.
Joost P.M. van Meerwijk, Joost P.M. van Meerwijk, Olivier Joffre   +2 more
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Loss of chromosome Y in regulatory T cells

BMC Genomics
Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer.
Jonas Mattisson, Jonatan Halvardson, Hanna Davies, Bożena Bruhn-Olszewska, Paweł Olszewski, Marcus Danielsson, Josefin Bjurling, Amanda Lindberg, Ammar Zaghlool, Edyta Rychlicka-Buniowska, Jan P. Dumanski, Lars A. Forsberg   +11 more
doaj   +1 more source

Ação dos linfócitos T regulatórios em transplantes T regulatory lymphocytes action in transplants

Revista Brasileira de Hematologia e Hemoterapia, 2008
O sistema imunológico humano possui um significado comum de proteção contra antígenos estranhos com potencialidade patogênica ou não, ativando uma ação coletiva e coordenada entre células e moléculas. Embora sendo um sistema benéfico, deve ser controlado
Bruno A. Faria, Simone M. Silva, Maria Theresa C. L. Abreu, Marcelo H. Napimoga   +3 more
doaj   +1 more source

Selective inhibition of T suppressor-cell function by a monosaccharide [PDF]

, 1981
Interactions between regulatory T lymphocytes and other cells are assumed to occur at the level of the cell surface. T cells which suppress the generation of specifically effector cells have been described as having antigenic, idiotypic, allotypic and I ...
AA Moscona, B Benacerraf, CG Orosz, DH Boldt, DL Peavy, FM Rollwagen, H Lis, IFC McKenzie, J Moss, JE Geltosky, K Eichmann, LA Herzenberg, LB Grabel, LM Nadler, Michael Kramer, RE Rocklin, RM Ferguson, RW Dutton, SH Barondes, T Tada, U Koszinowski, Ulrich H. Koszinowski, VT Marchesi   +22 more
core   +1 more source

A Nonconventional Analysis of CD$4^{+}$ and CD$8^{+}$ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection [PDF]

arXiv, 2017
A mathematical model from a previous work was re-fitted and analyzed for experimental data regarding the cellular immune response to the lymphocytic choriomeningitis virus. Specifically, the $CD8^{+}$ T cell response to six MHC class I-restricted epitopes (GP* and NP*) and $CD4^{+}$ T cell responses to two MHC class II-restricted epitopes\cite ...
arxiv  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Decrease of Tumor-infiltrating Regulatory T Cells Using Pentoxifylline: An Ex Vivo Analysis in Triple-negative Breast Cancer Mouse Model

Iranian Journal of Allergy, Asthma and Immunology, 2022
Triple-negative breast cancer (TNBC) is the most aggressive type of BC with the highest percentage of tumor-infiltrating lymphocytes (TILs). Hence, TIL therapy is considered a promising approach to target TNBC. Depletion of regulatory T cells (Tregs) in
Mohammad Hossein Kazemi, Mahdieh Shokrollahi Barough, Alireza Ghanavatinejad, Zahra Momeni-Varposhti, Samaneh Khorrami, Behnam Sadeghi, Reza Falak   +6 more
doaj  

Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes [PDF]

The Journal of Immunology, 2006
AbstractTolerance in vivo is maintained by multiple mechanisms that function to prevent autoimmunity. An encounter of CD4+ T cells with a circulating self-Ag leads to partial thymic deletion, the development of CD25+ regulatory T cells (Tregs), and functional anergy in the surviving CD25− population.
Jens G. Lohr, Lisa Wong, Birgit Knoechel, Lara J. Ausubel, Donglei Hu, Abul K. Abbas, Shirley Zhu   +6 more
openaire   +3 more sources