Results 121 to 130 of about 1,033,187 (394)

Controlling IL-7 injections in HIV-infected patients [PDF]

arXiv, 2018
Immune interventions consisting in repeated injection are broadly used as they are thought to improve the quantity and the quality of the immune response. However, they also raised several questions that remains unanswered, in particular the number of injections to make or the delay to respect between different injections to acheive this goal ...
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Influence exerted by helicobacter pylori on regulatory t-cells differentiation

Analiz Riska Zdorovʹû, 2017
Estimating risks of infections induced by gram-negative Helicobacter pylori, is a vital problem for healthcare due to wide spread of the agent and wide range of induced pathologies which include malignant neoplasms in gastrointestinal tract.
А.V. Matveichev, М.V. Talaeva, V.Yu. Talaev , N.V. Neumoina , K.M. Perfilova, D.G. Lapaev , E.V. Mokhonova , M.I. Tsyganova, V.N. Koptelova, Z.I. Nikitina , V.A. Lapin, D.A. Melent'ev   +11 more
doaj   +1 more source

T Cell Lineage Commitment: Identity and Renunciation [PDF]

, 2011
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterward.
Rothenberg, Ellen V.
core  

Transcription factor expression dynamics of early T-lymphocyte specification and commitment [PDF]

, 2009
Mammalian T lymphocytes are a prototype for development from adult pluripotent stem cells. While T-cell specification is driven by Notch signaling, T-lineage commitment is only finalized after prolonged Notch activation.
Anderson, Michele K., Butler, Robert, Buzi, Gentian, David-Fung, Elizabeth-Sharon, Diamond, Rochelle A., Rothenberg, Ellen V., Rowen, Lee, Yui, Mary A.   +7 more
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A Systematic Review of the Frequency of Regulatory T Cells in Hepatitis B and Hepatitis C

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Background: Regulatory T cells (Tregs) play an important role in sustaining the hepatitis B and C viruses (HBV and HCV) persistence and protecting the liver tissues from cytokine-associated detrimental effects through unclear mechanisms.
Tri Nugraha Susilawati, Atik Susianto
doaj   +1 more source

CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice.

Gastroenterology, 2006
BACKGROUND & AIMS Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4+ T lymphocytes have recently attracted the most attention, CD8+ regulatory T-cell populations are also believed to play ...
Ingrid Ménager-Marcq, Céline Pomié, P. Romagnoli, J. V. van Meerwijk   +3 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer

Heliyon, 2020
Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar, Yasmin Vahidi, Maryam Fakhimi, Ardalan Asadollahpour, Nasrollah Erfani, Zahra Faghih   +5 more
doaj