Results 271 to 280 of about 1,033,187 (394)

Microvesicular fat, inter cellular adhesion molecule‐1 and regulatory T‐lymphocytes are of importance for the inflammatory process in livers with non‐alcoholic steatohepatitis

Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 2011
C. Söderberg, J. Marmur, K. Eckes, H. Glaumann, M. Sällberg, L. Frelin, P. Rosenberg, P. Stål, R. Hultcrantz   +8 more
semanticscholar   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Prognostic significance of regulatory T lymphocytes in patients with hepatocellular carcinoma. [PDF]

J Zhejiang Univ Sci B, 2016
Zhang AB, Qian YG, Zheng SS.
europepmc   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, EarlyView.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinghui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

Autoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis

Proceedings of the National Academy of Sciences of the United States of America, 2011
Céline Pomié, R. Vicente, Yirajen Vuddamalay, B. A. Lundgren, Mark van der Hoek, G. Enault, J. Kagan, N. Fazilleau, H. Scott, P. Romagnoli, J. V. van Meerwijk   +10 more
semanticscholar   +1 more source

Response by Bansal et al to Letter Regarding Article, "Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy". [PDF]

Circulation, 2019
Bansal SS, Ismahil MA, Goel M, Zhou G, Rokosh G, Hamid T, Prabhu SD.   +6 more
europepmc   +1 more source

Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts

, 2005
Arturo Jiménez‐Periáñez, Gloria Ojeda, Gabriel Criado, Alejandra Sánchez, Eliana Pini, Joaquı́n Madrenas, José María Rojo, Pilàr Portolés   +7 more
openalex   +1 more source

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

Proceedings of the National Academy of Sciences of the United States of America, 2010
Dorothea Busse, Maurus de la Rosa, Kirstin Hobiger, K. Thurley, M. Flossdorf, A. Scheffold, T. Höfer   +6 more
semanticscholar   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Description of CD8⁺ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer. [PDF]

J Immunol Res, 2018
Vieyra-Lobato MR, Vela-Ojeda J, Montiel-Cervantes L, López-Santiago R, Moreno-Lafont MC.   +4 more
europepmc   +1 more source