Results 81 to 90 of about 1,033,187 (394)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Regulatory T cells in children with recently diagnosed type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2012
Background: Regulatory T cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes (T1D).
Asmaa Mohamed Zahran, Khalid Ibrahem Elsayh, Kotb Abbass Metwalley   +2 more
doaj   +1 more source

The Prognostic Importance of CD20(+) B lymphocytes in Colorectal Cancer and the Relation to Other Immune Cell subsets [PDF]

, 2019
The anti-tumour immune response is critical to patient prognosis in colorectal cancer (CRC). The aim of this study was to investigate infiltration of B lymphocytes into CRC tumours, and their clinical relevance, prognostic value and relation to other ...
Böckelman, Camilla, Edin, Sofia, Gunnarsson, Ulf, Haglund, Caj, Hagström, Jaana, Kaprio, Tuomas, Larsson, Pär, Mustonen, Harri, Palmqvist, Richard, Strigård, Karin   +9 more
core   +1 more source

Regulatory T lymphocytes attenuate myocardial infarction-induced ventricular remodeling in mice.

International Heart Journal, 2011
Downregulation of CD4+CD25+ regulatory T lymphocytes (Treg) has been found in local atherosclerotic lesions and in patients with myocardial infarction (MI).
Kazuaki Matsumoto, M. Ogawa, J. Suzuki, Y. Hirata, R. Nagai, M. Isobe   +5 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS

Медицинская иммунология, 2014
We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by ...
I. V. Nekrasova, S. V. Shirshev, I. Yu. Danchenko   +2 more
doaj   +1 more source

The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study [PDF]

, 2015
T regulator lymphocytes (Tregs) play a key role in the maintenance of immune tolerance and in the development of autoimmune diseases. Expression of Foxp3 is specific for Tregs, and can be used for the identification of these cells.
Afeltra, Antonella, Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Liberatori, Marta, Margiotta, Domenico Paolo Emanuele, ROSSI FANELLI, Filippo, Taffon, Chiara   +8 more
core   +1 more source

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach [PDF]

, 2020
Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children.
arxiv   +1 more source

Regulatory T and B lymphocytes in a spontaneous autoimmune polyneuropathy [PDF]

Clinical and Experimental Immunology, 2016
SummaryB7-2–/– non-obese diabetic (NOD) mice develop a spontaneous autoimmune polyneuropathy (SAP) that mimics the progressive form of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). In this study, we focused on the role of regulatory T cells (Tregs) and regulatory B cells (Bregs) in SAP.
Pretty Mary Abraham, Jian Rong Sheng, Songhua Quan, Betty Soliven   +3 more
openaire   +3 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source