Results 51 to 60 of about 40,864 (198)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Effect of water film and paste film thicknesses on printability of 3D printed low cement UHPC

open access: yesCase Studies in Construction Materials
To address the limitations of 3D printed concrete, such as low ductility and susceptibility to cracking, the development of 3D printed low cement ultra-high performance concrete (3DP-LC-UHPC) represents an effective approach.
Ye Shi   +4 more
doaj   +1 more source

Experimental Investigation of Steel Plate Shear Walls under Shear-Compression Interaction

open access: yesShock and Vibration, 2019
Four scaled one-storey single-bay steel plate shear wall (SPSW) specimens with unstiffened panels were tested to determine their behaviour under cyclic loadings. The shear walls had moment-resisting beam-to-column connections.
Yang Lv   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Concrete Gas Permeability: Implications for Hydrogen Storage Applications

open access: yesApplied Sciences
Concrete is widely utilized across various industries as a containment material. One essential property related to its performance is permeability, which determines its ability to allow the passage of gases or liquids through its pores and capillaries ...
Luana Abreu Araujo   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Reconstruction Modeling and Validation of Brown Croaker (Miichthys miiuy) Vocalizations Using Wavelet-Based Inversion and Deep Learning

open access: yesSensors
Fish species’ biological vocalizations serve as essential acoustic signatures for passive acoustic monitoring (PAM) and ecological assessments. However, limited availability of high-quality acoustic recordings, particularly for region-specific species ...
Sunhyo Kim   +7 more
doaj   +1 more source

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