Results 71 to 80 of about 1,157,336 (324)

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Experimental Investigation of Steel Plate Shear Walls under Shear-Compression Interaction

Shock and Vibration, 2019
Four scaled one-storey single-bay steel plate shear wall (SPSW) specimens with unstiffened panels were tested to determine their behaviour under cyclic loadings. The shear walls had moment-resisting beam-to-column connections.
Yang Lv, Ling Li, Di Wu, Bo Zhong, Yu Chen, Nawawi Chouw   +5 more
doaj   +1 more source

Selection in Scale-Free Small World

, 2005
In this paper we compare the performance characteristics of our selection based learning algorithm for Web crawlers with the characteristics of the reinforcement learning algorithm. The task of the crawlers is to find new information on the Web.
Farkas, Cs., Lorincz, A., Palotai, Zs.
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Concrete Gas Permeability: Implications for Hydrogen Storage Applications

Applied Sciences
Concrete is widely utilized across various industries as a containment material. One essential property related to its performance is permeability, which determines its ability to allow the passage of gases or liquids through its pores and capillaries ...
Luana Abreu Araujo, Nuria Rebolledo Ramos, Julio Emilio Torres Martín, Servando Chinchón-Payá, Javier Sánchez Montero, Rosa Maria Lample Carreras, Jose Vera-Agullo, Jose David Jimenez-Vicaria   +7 more
doaj   +1 more source

THE SUBSTITUTABILITY OF REINFORCERS [PDF]

Journal of the Experimental Analysis of Behavior, 1993
Substitutability is a construct borrowed from microeconomics that describes a continuum of possible interactions among the reinforcers in a given situation. Highly substitutable reinforcers, which occupy one end of the continuum, are readily traded for each other due to their functional similarity.
Leonard Green, Debra E. Freed
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Atari games and Intel processors

, 2017
The asynchronous nature of the state-of-the-art reinforcement learning algorithms such as the Asynchronous Advantage Actor-Critic algorithm, makes them exceptionally suitable for CPU computations.
Adamski, Robert, Grel, Tomasz, Klimek, Maciej, Michalewski, Henryk   +3 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

External Prestressing Bridge Reinforcement Technology Review

MATEC Web of Conferences, 2015
Externally prestressed bridge can not only limit and reduce the cracks and deformation of the structure, improve the rigidity and bearing capacity of structure, improve the stress state of structure, but also have less interference for bridge operation ...
Zhu Hanbing, Yang Yaxun, Fan Weiya
doaj   +1 more source