Results 71 to 80 of about 363,719 (298)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

A Study on the Coastline Extraction and Coastal Change Analysis Using Sentinel-2 Imagery in Funafuti, Tuvalu

Remote Sensing
Temporal alterations in coastlines depict the significant changes in coastal areas, driven by both natural processes and human activities. For island nations, monitoring of the coastline is essential due to their vulnerability to such impacts.
Sree Juwel Kumar Chowdhury, Chan-Su Yang
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Influence of crossing fault position and site soil on the mechanical properties of bellows joint connected buried pipelines under direct shear

Urban Lifeline
Buried pipeline systems are vulnerable to joint damage in earthquakes. Previous studies have shown that bellows joints are effective in increasing deformation capacity and reducing the axial force of the main pipeline.
Fang-fang Li, Guoxing Lu, Yang Lv, Xue-jie Zhang, Guo-bo Wang, Bo Zhong   +5 more
doaj   +1 more source

REINFORCEMENT OF INHIBITION [PDF]

Journal of the Experimental Analysis of Behavior, 1983
A differential‐reinforcement‐of‐other‐behavior (DRO) schedule with trials and delayed reinforcement was investigated. Periodically a wheel was briefly available to rats, followed six seconds later by brief availability of a bar. Variable‐ratio food reinforcement of wheel turns was adjusted to give 95% turns.
openaire   +3 more sources

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

INTER‐RESPONSE TIME DISTRIBUTION AS A FUNCTION OF DIFFERENTIAL REINFORCEMENT OF TEMPORALLY SPACED RESPONSES [PDF]

, 1959
Roger T. Kelleher, William Fry, Leonard Cook   +2 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Damage Characteristics Analysis of High-Rise Frame-Core-Tube Building Structures in Soft Soil Under Earthquake Action

Buildings
This paper analyzes the seismic performance and damage characteristics of high-rise frame-core-tube structures on soft soil, explicitly incorporating dynamic soil–pile–structure interaction (SSI).
Jiali Liang, Shifeng Sun, Gaole Zhang, Dai Wang, Yong Yu, Jihu Wu, Krzysztof Robert Czech   +6 more
doaj   +1 more source