Results 121 to 130 of about 196,068 (330)

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Learning to schedule job-shop problems: representation and policy learning using graph neural network and reinforcement learning [PDF]

, 2021
Junyoung Park, Junyoung Park, Jaehyeong Chun, Sang Hun Kim, Youngkook Kim, Jinkyoo Park, Jinkyoo Park   +6 more
openalex   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

After a Hand Was Lent: Sporadically Experiencing Multisensory Interference During the Rubber Hand Illusion Does Not Shield Against Disembodiment

Journal of Cognition
Observations from multisensory body illusions indicate that the body representation can be adapted to changing task demands, e.g., it can be expanded to integrate external objects based on current sensorimotor experience (embodiment).
Julia Eck, David Dignath, Andreas Kalckert, Roland Pfister   +3 more
doaj   +1 more source

Total Road Closure Vs. Partial Closure – Insights for Road Project Scheduling Using a Reinforcement Learning-Based Approach

, 2022
Sania E. Seilabi, Mostafa Saneii, Mohammadhosein Pourgholamali, Mohammad Miralinaghi, Samuel Labi   +4 more
openalex   +1 more source

User Scheduling and Beam-Selection with Tabular and Deep Reinforcement Learning [PDF]

, 2022
Rebecca Almeida Aben-Athar, Cleverson Nahum, Davi da Silva Brilhante, José Ferreira de Rezende, Luciano Leonel Mendes, Aldebaro Klautau   +5 more
openalex   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

NICE: Robust Scheduling through Reinforcement Learning-Guided Integer Programming [PDF]

, 2021
Luke Kenworthy, Siddharth Nayak, Christopher Chin, Hamsa Balakrishnan   +3 more
openalex   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Selected schedules of reinforcement in the black-tailed prairie dog (Cynomys ludovicianus) [PDF]

, 1978
Gene E. Todd, Dennis C. Cogan
openalex   +1 more source