Results 91 to 100 of about 17,592 (257)

Astrocyte Ca2+ in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking

Frontiers in Cellular Neuroscience
Recent literature supports a prominent role for astrocytes in regulation of drug-seeking behaviors. The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca2+.
Navid S. Tavakoli, Samantha G. Malone, Tanner L. Anderson, Ryson E. Neeley, Artin Asadipooya, Michael T. Bardo, Pavel I. Ortinski   +6 more
doaj   +1 more source

Rock mechanical properties under reconstructed deep in situ thermo–hydro–mechanical conditions: Implications for CO₂‐related injection scenarios

Deep Underground Science and Engineering, EarlyView.
The graphical abstract illustrates a reconstructed in situ thermo‐hydro‐mechanical (THM) framework in which porosity serves as the central variable linking stress, pore pressure, and temperature to evolving mechanical properties of rocks. Under burial conditions, in situ stress, pore pressure, and temperature jointly govern volumetric strain and ...
Mingyuan Lu, Jun Wang, Zixiong Qi, Ruixuan Chen, Hongtao Wang, Hongwei Zhou   +5 more
wiley   +1 more source

How to reduce sampling error in species population monitoring: from theory to methods

Ecography, EarlyView.
Progress towards national and international targets to halt and reverse declines in species' abundances will be assessed using multispecies indicators (MSIs). A distinction must be drawn between two MSIs. One is the ideal, but unobserved, MSI that would have been measured had all species and sites within the scope of the target been sampled.
Robin J. Boyd, Susan Jarvis, Xiao‐Li Meng, Gary D. Powney, Rebecca Spake, Oliver L. Pescott   +5 more
wiley   +1 more source

Preclinical Evaluation of Dual NOP/Mu Partial Agonists for Methamphetamine Use Disorder

Pharmaceuticals
Background/Objectives: Methamphetamine (meth) use disorder (MUD) continues to pose a significant public health challenge, and there are currently no FDA-approved pharmacological treatments available.
Thamires Righi, Gilles Zribi, Sebastian Garcia, Stephen M. Husbands, Lawrence Toll, Andrea Cippitelli   +5 more
doaj   +1 more source

Context Reinstatement

, 2020
Context reinstatement is the process by which we incorporate thoughts from our past into our current mental state. This chapter is concerned with characterizing the cognitive and neuropsychological underpinnings of context reinstatement. Modern theories of context reinstatement are inextricably tied to theories of how we process and perceive the ...
openaire   +2 more sources

The burden of the postictal state in epilepsy: A prospective, single‐center observational cohort study

Epileptic Disorders, EarlyView.
Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity ...
Ionuț‐Flavius Bratu, Agnès Trébuchon, Fabrice Bartolomei   +2 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Eye tracking evidence for the reinstatement of emotionally negative and neutral memories.

PLoS ONE
Recent eye tracking studies have linked gaze reinstatement-when eye movements from encoding are reinstated during retrieval-with memory performance. In this study, we investigated whether gaze reinstatement is influenced by the affective salience of ...
Paula P Brooks, Brigitte A Guzman, Elizabeth A Kensinger, Kenneth A Norman, Maureen Ritchey   +4 more
doaj   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source