Results 71 to 80 of about 107,620 (301)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking.

Frontiers in Behavioral Neuroscience, 2013
Stimuli previously associated with drugs of abuse can become triggers that elicit craving and lead to drug-seeking behavior. The basolateral amygdala (BLA) is a key neural structure involved in cue-induced reinstatement of cocaine seeking.
Michael T. Stefanik, Peter W. Kalivas
doaj   +1 more source

17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors [PDF]

, 2018
Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle.
Barron, Laura M., DeBaker, Margot C., Doncheck, Elizabeth M., Frick, Karyn M., Hillard, Cecilia J, Liddiard, Gage T., Mantsch, John, Tuscher, Jennifer J., Urbanik, Luke A.   +8 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Land Use Dynamics of Drove Roads: The Case of Tratturo Castel di Sangro-Lucera (Molise, Italy)

Land, 2018
Organized transhumant pastoralism has contributed to shaping the cultural landscape of many countries. It has affected areas designated for grazing, temporary and permanent shelters, and towns.
Michele Minotti, Carmen Giancola, Piera Di Marzio, Paolo Di Martino   +3 more
doaj   +1 more source

Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

eLife, 2020
Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory.
Alexandra N Trelle, Valerie A Carr, Scott A Guerin, Monica K Thieu, Manasi Jayakumar, Wanjia Guo, Ayesha Nadiadwala, Nicole K Corso, Madison P Hunt, Celia P Litovsky, Natalie J Tanner, Gayle K Deutsch, Jeffrey D Bernstein, Marc B Harrison, Anna M Khazenzon, Jiefeng Jiang, Sharon J Sha, Carolyn A Fredericks, Brian K Rutt, Elizabeth C Mormino, Geoffrey A Kerchner, Anthony D Wagner   +21 more
doaj   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

The promises and pitfalls of retrieval-extinction procedures in preventing relapse to drug seeking

Frontiers in Psychiatry, 2013
Relapse to drug seeking after treatment or a period of abstinence remains a fundamental challenge for drug users. The retrieval – extinction procedure offers promise in augmenting the efficacy of exposure based treatment for drug use and for protecting ...
Gavan P McNally, Kathryn Elizabeth Hutton-Bedbrook   +1 more
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source