Results 81 to 90 of about 107,620 (301)
Frontiers in Psychology, 2015 The present experiment investigated potential reinstaters of suboptimal economic decision making in rats. Rats were first trained on a version of the rat Gambling Task under conditions designed to promote choice of a suboptimal option that occasionally ...
Nina P. Connolly +3 more
doaj +1 more source
Policy and Practice Brief: Expedited Reinstatement of Social Security or SSI Disability Benefits [PDF]
, 2006 This brief covers the expedited reinstatement (EXR) provision, introduced into the Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI) programs in January 2001.
Sheldon, James R.
core +1 more source
Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
Advanced Science, EarlyView.Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun +5 more
wiley +1 more source
Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex [PDF]
, 2018 Background Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “set the
Baker, David A. +10 more
core +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
Frontiers in Psychiatry, 2013 Stress and anxiety play an important role in the development and maintanence of drug and alcohol addiction. The bed nucleus of the stria terminalis (BNST), a brain region involved in the production of long-term stress related behaviors, plays an ...
Yuval eSilberman, Danny G. Winder
doaj +1 more source
Mental context reinstatement reduces resistance to false suggestions after children have experienced a repeated event [PDF]
, 2010 When children allege repeated abuse, they are required to provide details about specific instances. This often results in children confusing details from different instances and so we examined whether ‘mental context reinstatement’ (MCR) could be used to
Jennings, Donna M. +2 more
core +1 more source
Refresh my memory: Episodic memory reinstatements intrude on working memory maintenance [PDF]
, 2017 A fundamental question in memory research is how different forms of memory interact. Previous research has shown that people rely on working memory (WM) in short-term recognition tasks; a common view is that episodic memory (EM) only influences ...
Bornstein, Aaron +3 more
core +1 more source
Advanced Science, EarlyView.ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li +8 more
wiley +1 more source
LifeSynthetic cathinones have gained increasing popularity in the illicit drug market, yet their abuse potential remains poorly understood. In this study, zebrafish were used to compare the addictive potential of three cathinone analogs, namely pentylone ...
Liao-Chen Chen +2 more
doaj +1 more source