Results 61 to 70 of about 30,265 (314)

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

open access: yesCell Reports, 2018
Summary: Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive.
Geraldine Gontier   +6 more
doaj   +1 more source

Facial Augmentation by Intra-Oral Delivery of Autologous Fat [PDF]

open access: yesArchives of Aesthetic Plastic Surgery, 2016
Background As harvesting techniques have improved the viability of transposed adipose tissue, autologous fat transfer is increasingly utilized for facial augmentation.
Libby R. Copeland-Halperin   +1 more
doaj   +1 more source

Rejuvenation of ‘Make in India’

open access: yesWorld Journal of Advanced Research and Reviews, 2023
Initially, Covid-19 outbreak drew the progressive economy towards regression, but later with India being seen as a prime investment destination over China exacerbating the current scenario, there is a comeback of the failed campaign ‘Make In India’ to light, with global pharmaceuticals companies eyeing on India.
Caleb, Mervin Felix, AC, Kiran Kumar
openaire   +2 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

In Vitro and In Vivo Assessment of an Innovative Peeling System with Azelaic and Tranexamic Acids for Targeted Hyperpigmentation Reduction

open access: yesDermatology and Therapy
Introduction Melanin, derived from tyrosine, plays a pivotal role in skin pigmentation through melanogenesis. Disruptions in this process lead to hyperpigmentation, a condition affecting skin tone and quality of life.
Russell Wong   +6 more
doaj   +1 more source

PPARgamma Deficiency Counteracts Thymic Senescence

open access: yesFrontiers in Immunology, 2017
Thymic senescence contributes to increased incidence of infection, cancer and autoimmunity at senior ages. This process manifests as adipose involution. As with other adipose tissues, thymic adipose involution is also controlled by PPARgamma.
David Ernszt   +10 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

LASMIK laser biorevitalization: mechanisms and therapeutic experience

open access: yesDermatology Reports, 2020
LASMIK laser biorevitalization is a well-known technology developed in Russia that is based on laser phoresis as a method to enhance percutaneous penetration of substances. The article describes the mechanisms that act here and factors that determine the
Sergey Vladimirovich Moskvin   +1 more
doaj   +1 more source

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