Results 81 to 90 of about 104,614 (297)

Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies

Frontiers in Cell and Developmental Biology, 2020
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and differentiation. There is increasing evidence of the therapeutic value of MSCs in various clinical situations, however, these cells gradually lose their regenerative ...
Jing Liu, Jing Liu, Yue Ding, Zhongmin Liu, Zhongmin Liu, Xiaoting Liang, Xiaoting Liang   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions

Biology Direct
Over the last few decades, adipose tissue has attracted increasing attention in the field of regenerative medicine, thanks to discoveries related to its regenerative, anti-inflammatory, and pro-angiogenic properties.
Silvia Gandolfi, Elise Lupon, Audrey Varin, Agnes Coste, Brigitte Sallerin, Carla Boyer, Yanis Berkane, Benoit Chaput   +7 more
doaj   +1 more source

Memory effects in response functions of driven vortex matter

, 2001
Vortex flow in driven type II superconductors shows strong memory and history dependent effects. Here, we study a schematic microscopic model of driven vortices to propose a scenario for a broad set of these kind of phenomena ranging from ``rejuvenation''
, , Bassler K. E., Binder K., Bouchaud J. P., Brandt E. H., Cohen L. F., H. Jeldtoft Jensen, Jackson D. K., Lefloch F., M Nicodemi, Nicodemi M., Nicodemi M., Nicodemi M., Schmittmann B.   +14 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aquifer hydraulic characteristics using D-Z parameters: a case study of Lohaghat block, Champawat district, Uttarakhand, India

Discover Applied Sciences
This study investigates the geoelectrical properties of shallow aquifers and estimates their hydraulic parameters in the Lohaghat block of the Champawat district, Uttarakhand.
Somvir Singh, Nepal C. Mondal
doaj   +1 more source

Elastostatic loading rejuvenation behavior in bulk metallic glasses and its origin: A review

Journal of Materials Research and Technology
Bulk metallic glasses (BMGs) that exhibit superior properties compared to their crystalline counterparts, such as high strength, excellent corrosion resistance and good magnetic properties, are emerging as advanced engineering materials.
Seyyedeh Maryam Mirhashemi, Mehdi Malekan   +1 more
doaj   +1 more source

Memory Effect, Rejuvenation and Chaos Effect in the Multi-layer Random Energy Model

, 2000
We introduce magnetization to the Multi-layer Random Energy Model which has a hierarchical structure, and perform Monte Carlo simulation to observe the behavior of ac-susceptibility.
Andersson J. O., Andersson J. O., Bouchaud J. P., Bray A. J., Derrida B., Derrida B., Fisher D. S., Granberg P., Granberg P., Jonason K., Koper G. J. M., Lefloch F., Lundgren L., Nemoto K., Refreggier Ph., Sasaki M., Shulze C., Sibani P., Svedlindh P., Villain J., Vincent E., Yoshino H.   +21 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

In Vitro and In Vivo Assessment of an Innovative Peeling System with Azelaic and Tranexamic Acids for Targeted Hyperpigmentation Reduction

Dermatology and Therapy
Introduction Melanin, derived from tyrosine, plays a pivotal role in skin pigmentation through melanogenesis. Disruptions in this process lead to hyperpigmentation, a condition affecting skin tone and quality of life.
Russell Wong, Mariangela G. de O. Sichmann, James Sun, Alexis R. Kim, Robert J. Bianchini, Kevin D. Hermanson, Louis Chabert   +6 more
doaj   +1 more source