Results 91 to 100 of about 40,752 (251)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
MathematicsMobile edge computing storage is increasingly used to support immersive services and Internet of Things applications that generate continuous real-time data streams.
Tuan Anh Nguyen +3 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2023 Gladstone EL Faria, Juliana S Palo, Andre R Torres, Ana CHR Machado, Ricardo F Boggio Cosmiatry Department, Instituto Boggio, São Paulo, SP, BrazilCorrespondence: Gladstone EL Faria, Cosmiatry Department, Instituto Boggio, Rua Cincinato Braga nr 37.
Faria GE +4 more
doaj
, 2016 Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2 1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France *These authors contributed equally to this work Abstract: Skin aging is primarily due to alterations in ...
Leventhal PS +2 more
core
Software Ageing and Rejuvenation: Where We Are and Where We Are Going
, 2011 After 16 years, a significant body of knowledge has been established in the area of Software Aging and Rejuvenation (SAR). In this paper, we survey papers about SAR that appeared in IEEE conferences and journals, identify where SAR research has been ...
COTRONEO, DOMENICO +7 more
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures
, 2010 Alberto Goldman1, Uwe Wollina21Clinica Goldman, Porto Alegre, RS, Brazil; 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, GermanyAbstract: Facial ...
Alberto Goldman, Uwe Wollina
core
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Bio-graded recycling for hot asphalt mixtures with high RAP content considering freeze-thaw
Frontiers in MaterialsThis paper investigates the effects of freeze-thaw cycles on the performance of asphalt mixtures containing 60% rejuvenated asphalt pavement (RAP). Two rejuvenation processes, traditional and bio-graded recycling, are compared regarding high-temperature ...
Liqiang He +6 more
doaj +1 more source