Results 91 to 100 of about 104,614 (297)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modulating the rejuvenation in a Al75Mg25 metallic glass by multiple recovery annealing treatment

Journal of Materials Research and Technology
Rejuvenation presents a promising way to improve the plasticity of metallic glasses. How modulating the degree of rejuvenation of metallic glasses remains a challenging issue. Here, based on the molecular dynamics simulation, we investigate the evolution
Xuelian Li, Chengyong Zhong, Xin Jin, Dongmei Li, Yueqi Li, Baoan Sun, Peng Yu   +6 more
doaj   +1 more source

Long Term Effects of Combination of Metabolite Product Amniotic Membrane Stem Cell (MP-AMSC) and Vitamin C after Fractional CO2 Laser for Photoaging Treatment

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2020
Background: Metabolite Products Amniotic Membrane Stem Cell (MP-AMSC) originating from the amniotic membrane has a skin rejuvenation effect by stimulating collagen synthesis. Vitamin C functions as an antioxidant in photoaging treatment.
Vidyani Adiningtyas, Muhammad Yulianto Listiawan, Linda Astari   +2 more
doaj   +1 more source

Analysis of Software Aging in a Web Server [PDF]

A number of recent studies have reported the phenomenon of “software aging”, characterized by progressive performance degradation and/or an increased occurrence rate of hang/crash failures of a software system due to the exhaustion of operating system ...
Grottke, Michael, Liz, Lei, Trivedi, Kishor S., Vaidyanathan, Kalyanaraman   +3 more
core  

Memory and rejuvenation in a spin glass

, 2010
The temperature dependence of the magnetisation of a Cu(Mn) spin glass ($T_g$ $\approx$ 57 K) has been investigated using weak probing magnetic fields ($H$ = 0.5 or 0 Oe) and specific thermal protocols.
Komori T., Lundgren L., M. Hudl, Mathieu R., P. Nordblad, Peddis D., R. Mathieu   +6 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

RELAX and FIRMNESS: The Combination of Muscle Relaxation with Botulinum Toxin and Collagen Biostimulation with Calcium Hydroxyapatite for the Treatment of the Cervical Region

Clinical, Cosmetic and Investigational Dermatology, 2023
Gladstone EL Faria, Juliana S Palo, Andre R Torres, Ana CHR Machado, Ricardo F Boggio Cosmiatry Department, Instituto Boggio, São Paulo, SP, BrazilCorrespondence: Gladstone EL Faria, Cosmiatry Department, Instituto Boggio, Rua Cincinato Braga nr 37.
Faria GE, Palo JS, Torres AR, Machado AC, Boggio RF   +4 more
doaj  

Aging, rejuvenation and memory effects in Ising and Heisenberg spin glasses

, 2001
We have compared aging phenomena in the Fe_{0.5}Mn_{0.5}TiO_3 Ising spin glass and in the CdCr_{1.7}In_{0.3}S_4 Heisenberg-like spin glass by means of low-frequency ac susceptibility measurements. At constant temperature, aging obeys the same `$\omega t$
A. Billoire, A. Ito, A. Ito, A. Ito, A. J. Bray, C. Djurberg, D. S. Fisher, D. S. Fisher, E. Marinari, E. Marinari, E. Vincent, E. Vincent, E. Vincent, F. Lefloch, G. J. M. Koper, H. Aruga, H. Aruga Katori, H. Bouchiat, H. Rieger, H. Yoshino, I. Campbell, J. Hammann, J. Hammann, J. Souletie, J.-P. Bouchaud, J.-P. Bouchaud, K. A. Meyer, K. Gunnarsson, K. Jonason, K. Jonason, L. F. Cugliandolo, L. F. Cugliandolo, M. Alba, M. Alba, M. B. Weissman, M. Picco, M. Picco, M. Sasaki, P. Svedlindh, P. Svedlindh, Ph. Refregier, S. Pouget, S. Pouget, T. Komori, T. Komori, T. Komori, V. Dupuis, Y. G. Joh   +47 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source