Results 61 to 70 of about 38,994 (299)

Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages

, 2016
On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are ...
Tao, Wei, Vaupel, James W, Yashin, Anatoli, Gottschalk, William, Feng, L, Qi, Ming, Willcox, Craig D, Bolund, Lars, Vaupel, JW, Ni, Ting, Willcox, DC, Gu, J, Willcox, D. Craig, Hauser, Elizabeth, Gottschalk, W, Willcox, Bradley, Zeng, Yi, Feng, Lei, Yang, H, Chen, Huashuai, Vaupel, James W., Zhang, Fengyu, Yang, Huanming, Gregory, Simon G., Tian, Xiao-Li, Land, Kenneth, Gregory, Simon G, Lu, Jiehua, Zeng, Y, Hauser, E, Bolund, L, Yang, Z, Nie, C, Land, KC, Ruan, Rongping, Tan, Qihua, Min, J, Ming, Qi, Tao, W, Liu, X, Land, Kenneth C., Min, Junxia, Li, J, Willcox, BJ, Yashin, A, Li, Jianxin, Nie, Chao, Yashin, Anatoli I, Yang, Ze, Gu, Jun, Tan, Q, Chen, H, Lutz, MW, Ni, T, Ruan, R, Ming, Q, Lutz, Michael W., Tian, X, Gregory, SG, Liu, Xiaomin, Lutz, Mike, Lu, J, Tan, Qihua; id_orcid, Zhang, F, Li, Y, Li, Yang, Willcox, Bradley J.   +66 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An Adaptive Reconfiguration Mechanism for Periodic Software Rejuvenation based on Transient Reliability Analysis

MATEC Web of Conferences, 2018
While software rejuvenation is used to prevent severe software failures, existing researches generally choose the constant-value periodic policy through steady-state reliability optimization.
He Pan, Liu Gang, Yuan Yue
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions

Biology Direct
Over the last few decades, adipose tissue has attracted increasing attention in the field of regenerative medicine, thanks to discoveries related to its regenerative, anti-inflammatory, and pro-angiogenic properties.
Silvia Gandolfi, Elise Lupon, Audrey Varin, Agnes Coste, Brigitte Sallerin, Carla Boyer, Yanis Berkane, Benoit Chaput   +7 more
doaj   +1 more source

Scrotal Rejuvenation [PDF]

Cureus, 2018
Genital rejuvenation is applicable not only to women (vaginal rejuvenation) but also to men (scrotal rejuvenation). There is an increased awareness, reflected by the number of published medical papers, of vaginal rejuvenation; however, rejuvenation of the scrotum has not received similar attention in the medical literature.
openaire   +2 more sources