Results 61 to 70 of about 104,614 (297)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes
Cosmetics, 2023 Laser-assisted drug delivery (LADD) has gained prominence as a promising technique with the potential to enhance topical drug skin penetration and absorption. However, the effectiveness of various laser-assisted facial procedures remains unclear.
Konstantinos Seretis +1 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Redox BiologyZinc is an essential trace mineral for human health. However, consuming large amounts of zinc can be toxic. Therefore, zinc homeostasis must be actively regulated. Within cells, zinc mostly exists in a form bound with proteins. We show that the existence
Katarzyna Jonak, Ulrike Topf
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. [PDF]
, 2019 Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of ...
Albarran, Eddy +8 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
A microscopic mechanism for rejuvenation and memory effects in spin glasses
, 2001 Aging in spin glasses (and in some other systems) reveals astonishing effects of `rejuvenation and memory' upon temperature changes. In this paper, we propose microscopic mechanisms (at the scale of spin-spin interactions) which can be at the origin of ...
Miyashita, S., Vincent, E.
core +3 more sources
Lithic economies and community organization at La Laguna, Tlaxcala [PDF]
, 2016 Site-wide, assemblage-based lithic analyses help to elucidate community dynamics including variability in domestic economies, technological skill and decision making, exchange networks, and ritual practices.
Carballo, David M., Walton, David P.
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source