Results 41 to 50 of about 40,752 (251)

Planning Optimal Rejuvenation Policy for Aging Software Systems via a Two-Layer Model

IEEE Access, 2020
Software rejuvenation is a proactive fault management technique widely used for preventing performance degradation and failures due to software aging.
Jingwei Li, Yong Qi, Guanghua Wang, Jinwei Lin   +3 more
doaj   +1 more source

Fluorescent Light Energy (FLE) Generated through Red LED Light and a Natural Photoconverter Gel as a New, Non-Invasive Approach for Facial Age Control: A Pilot Study

Cosmetics, 2023
This study, for the first time, evaluated the safety and efficacy of a new natural-based topical gel containing a spirulina extract. This photoconverter gel generates fluorescent light energy (FLE) via a red LED light device, which is proven to be ...
Giuseppe Scarcella, Roberta Tardugno, Pasquale Crupi, Marilena Muraglia, Maria Lisa Clodoveo, Filomena Corbo   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Unlocking neuronal health: leveraging C. elegans for drug repurposing studies

Cell Communication and Signaling
Aging affects neuronal function, leading to both structural and functional changes in the human brain. The concomitant cognitive decline and neurodegenerative diseases drive efforts to find pharmaceutical drugs to ameliorate the consequences of neuron ...
Spoorthy Gowda, Arun Kumar, Ulrike Topf
doaj   +1 more source

In Vivo Skin Regeneration and Wound Healing Using Cell Micro-Transplantation

Pharmaceutics, 2022
Background: The accumulation of senescent cells in tissues alters tissue homeostasis and affects wound healing. It is also considered to be the main contributing factor to aging.
Lucia Nanić, Andrea Cedilak, Nikolina Škrobot Vidaček, Florian Gruber, Miljenko Huzak, Michael Bader, Ivica Rubelj   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Integrated analysis of the redoxome and zinc proteome links ribosomal protein oxidation to zinc homeostasis

Redox Biology
Zinc is an essential trace mineral for human health. However, consuming large amounts of zinc can be toxic. Therefore, zinc homeostasis must be actively regulated. Within cells, zinc mostly exists in a form bound with proteins. We show that the existence
Katarzyna Jonak, Ulrike Topf
doaj   +1 more source

The Old Woman’s Farcical Rejuvenation in The Rejuvenation of Miss Semaphore (1897)

Cahiers Victoriens et Edouardiens, 2022
Charlotte O’Conor Eccles’s The Rejuvenation of Miss Semaphore (1897) is a comedic New Woman narrative in which a lonely, middle-aged, single woman gets rejuvenated after drinking an elixir.
Somi Ahn
doaj   +1 more source

Cellular reprogramming and epigenetic rejuvenation [PDF]

, 2021
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible.
Olova, Nelly N.; id_orcid, Chandra, Tamir, Simpson, Daniel J., Tamir Chandra, Nelly N. Olova, Daniel J. Simpson   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source