Results 41 to 50 of about 38,994 (299)

The Software Aging and Rejuvenation Repository

, 2015
While Software Aging and Rejuvenation (SAR) research has been steadily increasing, the artifacts related to SAR studies (such as software aging measurements and bug datasets) are seldom made available to researchers and practitioners, thus limiting ...
COTRONEO, DOMENICO, Pietrantuono, R., NATELLA, ROBERTO, RUSSO, STEFANO, Roberto Natella, IANNILLO, ANTONIO KEN, Antonio Ken Iannillo, Domenico Cotroneo, Cotroneo, D., PIETRANTUONO, ROBERTO, Russo, S., Roberto Pietrantuono, Stefano Russo, Natella, R.   +13 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Software Rejuvenation - Do IT & Telco Industries Use It?

, 2012
Software rejuvenation has been addressed in hundreds of papers since it was proposed in 1995 by Huang et al. The growing number of research papers shows the great importance of this topic.
J. LI, Jinghui Li, Kishor Trivedi, J. ALONSO, RUSSO, STEFANO, Javier Alonso, Yakun Wang, Y. WANG, K. S. TRIVEDI, Antonio Bovenzi, Stefano Russo, BOVENZI, ANTONIO   +11 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Unlocking neuronal health: leveraging C. elegans for drug repurposing studies

Cell Communication and Signaling
Aging affects neuronal function, leading to both structural and functional changes in the human brain. The concomitant cognitive decline and neurodegenerative diseases drive efforts to find pharmaceutical drugs to ameliorate the consequences of neuron ...
Spoorthy Gowda, Arun Kumar, Ulrike Topf
doaj   +1 more source

Planning Optimal Rejuvenation Policy for Aging Software Systems via a Two-Layer Model

IEEE Access, 2020
Software rejuvenation is a proactive fault management technique widely used for preventing performance degradation and failures due to software aging.
Jingwei Li, Yong Qi, Guanghua Wang, Jinwei Lin   +3 more
doaj   +1 more source

In Vivo Skin Regeneration and Wound Healing Using Cell Micro-Transplantation

Pharmaceutics, 2022
Background: The accumulation of senescent cells in tissues alters tissue homeostasis and affects wound healing. It is also considered to be the main contributing factor to aging.
Lucia Nanić, Andrea Cedilak, Nikolina Škrobot Vidaček, Florian Gruber, Miljenko Huzak, Michael Bader, Ivica Rubelj   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source