Results 231 to 240 of about 153,606 (275)

A Hypothesis-Generating Pharmacologic Profile for Sargramostim Treatment of Parkinson's Disease. [PDF]

Cell Mol Neurobiol
Sil S, Du X, Akter S, Kumar M, Oludipe DB, Saha A, Hu G, Ostlund KR, Haynatzki GR, Santamaria P, Mosley RL, Gendelman HE.   +11 more
europepmc   +1 more source

The mecillinam resistome in <i>Klebsiella pneumoniae</i>: how resistance to a one-target β-lactam triggers a diversity of responses. [PDF]

Antimicrob Agents Chemother
Royer M, Cabanel N, Gutierrez A, Royer G, Barraud O, Naas T, Rosinski-Chupin I, Loverdo C, Glaser P.   +8 more
europepmc   +1 more source

Maternal serum from 'high-stress' pregnancies demonstrates bioactivity capable of attenuating neurite growth through a TNFα-dependent pathway in SH-SY5Y cells. [PDF]

Biosci Rep
Deady C, Wilmes L, McCarthy FP, Khashan AS, Clarke G, Keane J, McCarthy C, O'Keeffe GW, O'Mahony SM.   +8 more
europepmc   +1 more source

Activation of MyD88/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin. [PDF]

JID Innov
Trubetskoy D, Grudzien PK, Klopot A, Tsoi LC, Kundu RV, Perez White BE, Budunova I.   +6 more
europepmc   +1 more source

Elevated TNF-α level is correlated with NF-κB/p65 activation in patients with sporadic colorectal cancer. [PDF]

Mol Clin Oncol
Santana-Bejarano UF, Fernandez-Sanchez D, Bobadilla-Morales L, Brukman-Jimenez A, Valenzuela-Pérez JA, Corona-Rivera JR, Corona-Rivera A.   +6 more
europepmc   +1 more source

Exploring the role of tocotrienol-rich fraction (TRF) in ameliorating neuroinflammation. [PDF]

Inflammopharmacology
Tan JY, Retinasamy T, Lee VLL, Radhakrishnan AK, Yeong KY.   +4 more
europepmc   +1 more source

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Nonsense and insertion mutants in the relA gene of E. coli: Cloning relA

Cell, 1978
We have made use of lysogens of a specialized transducing bacteriophage, lambdapyrG+ relA+, to select nonsense (relAnon) and insertion (relAins) mutations in the relA gene. Three independent relAnon mutants were isolated on the phage. In all three, the relaxed phenotype was suppressed by supD, supE, supF or sup6.
J D, Friesen, G, An, N P, Fiil
openaire   +2 more sources

Combinatorial Selection and Edited Combinatorial Selection of Phosphorothioate Aptamers Targeting Human Nuclear Factor-κB RelA/p50 and RelA/RelA

Biochemistry, 2004
Nuclear factor-kappaB (NF-kappaB) transcription factors are important in regulating the immune response and play critical roles in the pathogenesis of chronic inflammatory diseases and a variety of human cancers. Agents that target specific NF-kappaB dimers may serve as therapeutic agents for the prevention of pathogenic immune responses.
Suzanne E, Bassett, Susan M, Fennewald, David J, King, Xin, Li, Norbert K, Herzog, Robert, Shope, Judy F, Aronson, Bruce A, Luxon, David G, Gorenstein   +8 more
openaire   +2 more sources

Regulation of the RelA (p65) transactivation domain

Biochemical Society Transactions, 2008
The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins.
O'Shea, John M., Perkins, Neil D.
openaire   +3 more sources