Results 111 to 120 of about 955,652 (295)

When to order a biopsy to characterise a metastatic relapse in breast cancer [PDF]

, 2012
Theodoros Foukakis, Gunnar Åström, Linda S. Lindström, Thomas Hatschek, Jonas Bergh   +4 more
openalex   +1 more source

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Verbal memory in major depressive disorder in a long-term perspective: a five-year longitudinal study of first episode patients

Frontiers in Psychiatry
IntroductionMajor depressive disorder (MDD) is associated with cognitive impairment, including verbal memory. Limited knowledge exists following memory performance in first episode (FE) MDD. This study investigated verbal memory, depressive symptoms, and
Marit Schmid, Marit Schmid, Eivind Haga Ronold, Eivind Haga Ronold, Maiken Løchen, Maiken Løchen, Åsa Hammar, Åsa Hammar, Åsa Hammar   +8 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Blue again: Perturbational effects of antidepressants suggest monoaminergic homeostasis in major depression

Frontiers in Psychology, 2011
Some evolutionary researchers have argued that current diagnostic criteria for major depressive disorder (MDD) may not accurately distinguish true instances of disorder from a normal, adaptive stress response.
Paul eAndrews, Paul eAndrews, Susan eKornstein, Lisa eHalberstadt, Charles eGardner, Michael C Neale   +5 more
doaj   +1 more source

Maintaining physical activity in cardiac rehabilitation [PDF]

, 2006
This chapter describes an intervention that has been used to encourage individuals to remain regularly physically active in exercise-based CR in phases III and IV.The principles of this intervention are also appropriate for allphases of CR.This ...
Hughes, Adrienne, Mutrie, Nanette
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The prognostic value and relationships of patient characteristics, estrogen and progestin receptors, and site of relapse in primary breast cancer [PDF]

, 1988
J. Alexieva-Figusch, Wim L.J. van Putten, Marinus A. Blankenstein, Joanna Blonk-van der Wijst, J.G.M. Klijn   +4 more
openalex   +1 more source