Results 111 to 120 of about 41,565 (267)

Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

Neural Regeneration Research, 2017
Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis ...
Rebecca M Heidker, Mitchell R Emerson, Steven M LeVine   +2 more
doaj   +1 more source

A patient with established primary progressive multiple sclerosis transitions to ‘secondary’ relapsing–remitting disease course following a fulminant demyelinating episode

, 2011
Primary progressive multiple sclerosis (PPMS), relapsing remitting MS (RRMS) and acute disseminated encephalomyelitis (ADEM) are clinically and immunopathogenetically distinct phenotypes of inflammatory demyelinating disorders of the central nervous ...
Orhun H Kantarci, Sabahattin Saip, Aksel Siva, Tutuncu, Melih, Demirci, Nuri O., Melih Tutuncu, Feriha Özer, Nuri O Demirci, Siva, Aksel, Kantarci, Orhun H., Ozer, Feriha, Saip, Sabahattin   +11 more
core   +1 more source

Personalized Treatment of Patients With Multiple Sclerosis: A Case Report and Literature Review

Medicine Bulletin, EarlyView.
ABSTRACT Managing multiple sclerosis (MS) with a highly active disease course presents significant challenges, particularly regarding the timing of therapeutic escalation and the preservation of brain volume. We present a personalized management strategy for a 36‐year‐old male with relapsing‐remitting MS (RRMS) who experienced initial misdiagnosis ...
Fengjun Wang, Han Wang, Yu Zhang, Guoxun Zhang   +3 more
wiley   +1 more source

Utility of Pelvic Floor Therapy and Behavioral Interventions in the Neurogenic Lower Urinary Tract Dysfunction (NLUTD) Population

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Neurogenic lower urinary tract dysfunction (NLUTD) describes a wide range of symptoms depending on neurologic diagnosis and the resulting bladder and sphincter dysfunction. This narrative review is designed to address the question regarding which NLUTD population benefits most from pelvic floor therapy and behavioral interventions, and ...
Sara M. Lenherr
wiley   +1 more source

Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: subgroup analyses from the phase 2b study

, 2011
Background: In a phase 2b study in patients with relapsing–remitting MS (RRMS), BG-12 240 mg three times daily significantly reduced the number of new gadolinium-enhanced (Gd+) lesions from weeks 12 to 24 (primary end point) by 69% compared with placebo.
Mefkure Eraksoy, Eraksoy, M., Eraksoy, Mefkure, O'Neill, G.N., Chris H Polman, Tarek A Yousry, Eva Meluzinova, Volker Limmroth, Minhua Yang, Havrdova, E., Gold, Ralf, Yang, Minhua, Limmroth, Volker, MacManus, D.G., Gilmore N O’Neill, Dufek, M., Meluzinova, E., Michal Dufek, Havrdova, Eva, Dawson, K., Schmierer, K., Miller, D. H., David G MacManus, Meluzinova, Eva, Polman, Chris H., Miller, David H., MacManus, David G., Ralf Gold, Schmierer, Klaus, Yousry, T.A., Ludwig Kappos, Yang, M.H., Yousry, Tarek A., O'Neill, Gilmore N., Eva Havrdova, Kappos, Ludwig, Polman, C.H., Klaus Schmierer, Kappos, L., Dufek, Michal, David H Miller, Limmroth, V., Dawson, Kate, Gold, R., Kate Dawson   +44 more
core   +1 more source

Urodynamic Voiding Patterns in Multiple Sclerosis

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims This study aimed to describe urodynamic voiding patterns in patients with MS (PwMS) using standardized assessments, and to compare the performance of the available nomograms and indices for obstruction and bladder contractility. Methods PwMS and lower urinary tract symptoms underwent cystometry and pressure flow studies.
Camille Chesnel, Nicolas Turmel, Maelys Teng, Emilie Blouet, Gérard Amarenco, Claire Hentzen   +5 more
wiley   +1 more source

A longitudinal study of abnormalities on MRI and disability from multiple sclerosis

, 2002
Background: In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as determined by T2-weighted magnetic resonance imaging (MRI) of ...
Ciccarelli, O., Thompson, A.J., Miller, D.H., Brex, P.A., O'Riordan, J.I., Sailer, M.   +5 more
core  

Real‐World Safety and Effectiveness of Glatiramer Acetate in Patients With Multiple Sclerosis: Final Results of Post‐Marketing Surveillance in Japan

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Glatiramer acetate is an injectable disease‐modifying therapy indicated for multiple sclerosis (MS). Aim To evaluate the real‐world safety and effectiveness of glatiramer acetate for MS in Japan. Methods A prospective, multicenter, observational, all‐case post‐marketing survey was conducted in Japan between November 2015 and March ...
Masaaki Niino, Eriko Hayashi, Mai Itani, Jun‐ichi Kira   +3 more
wiley   +1 more source

Soluble CD163 Levels Correlate with EDSS in Female Patients with Relapsing–Remitting Multiple Sclerosis Undergoing Teriflunomide Treatment

BioMed
Background: multiple sclerosis (MS) presentation varies depending on the location and severity of the lesions affecting different areas of the spinal cord and brain.
Mario Jerčić, Maja Rogić Vidaković, Anita Markotić, Nikolina Režić Mužinić   +3 more
doaj   +1 more source

Fear of falling is associated with physical functioning, activity performance, and participation in individuals with multiple sclerosis

PM&R, EarlyView.
Abstract Background Fear of falling (FoF) is a common concern in individuals with multiple sclerosis (MS). Understanding whether and how FoF affects activities and participation is crucial for developing effective rehabilitation programs in individuals with MS.
Libak Abou, Jeeyeon Kim, Chloe McCloskey, Cory Wernimont, Anna L. Kratz   +4 more
wiley   +1 more source