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Prophylaxis and treatment strategies for optimizing chemotherapy relative dose intensity
Expert Review of Anticancer Therapy, 2021 A decrease in relative-dose intensity (RDI) of chemotherapy has been shown to be associated with poor patient outcomes in solid tumors and non-Hodgkin's lymphoma. The actual delivered chemotherapy dose received by patients can be influenced by dose reductions and treatment delays, often due to toxicities, most commonly chemotherapy-induced neutropenia (
Michelle Shayne
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Relative dose intensity of FEC100: An analysis of outcomes
Journal of Clinical Oncology, 2005773 Background: Adjuvant FEC100 is considered to be highly effective at improving disease-free survival (DFS) and overall survival (OS) in patients (pts) with early breast cancer (EBC). Correlation between relative dose intensity (RDI) and outcomes of adjuvant therapy is primarily based on CMF data from Bonadonna (1981).
S. Hopkins +4 more
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Relative profile and dose verification of intensity-modulated radiation therapy
International Journal of Radiation Oncology*Biology*Physics, 2000To develop a quality assurance (QA) procedure to assess the intensity profile and dosimetry for intensity-modulated (IM) treatment fields using electronic portal imaging devices (EPIDs).A series of rapidly acquired (approximately 1/sec) portal images are summed and converted to dose.
J, Chang +4 more
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Gynecologic Oncology, 2011
Relative dose intensity (RDI) is the ratio of delivered dose intensity of chemotherapy to standard dose intensity. In this study, we sought to determine the prognostic significance of RDI in patients with epithelial ovarian cancer (EOC).A retrospective analysis of chemotherapy naïve patients treated between 2001 and 2008 with intravenous taxane and ...
Janelle M Fauci +2 more
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Relative dose intensity (RDI) is the ratio of delivered dose intensity of chemotherapy to standard dose intensity. In this study, we sought to determine the prognostic significance of RDI in patients with epithelial ovarian cancer (EOC).A retrospective analysis of chemotherapy naïve patients treated between 2001 and 2008 with intravenous taxane and ...
Janelle M Fauci +2 more
exaly +3 more sources
Relative dose intensity (RDI) assessment in an academic center.
Journal of Clinical Oncology, 2011139 Background: Patients with early breast cancer treated in the adjuvant setting realize maximum benefit as to disease- free and overall survival when they receive their full planned dose of chemotherapy. Due to the aggressive treatment regimens, patients are at increased risk of dose delays and reductions, which result in reduced RDI.
A. Arnaout +3 more
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A review of relative dose intensity and survival in patients with metastatic solid tumors
Critical Reviews in Oncology/Hematology, 2015Studies have shown that in the curative setting patients with cancer receiving chemotherapy at higher relative dose intensity (RDI) had better clinical outcomes than those receiving treatment at lower RDI. However, the impact of RDI in advanced/metastatic disease remains unclear.
Laura J, Havrilesky +4 more
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Relative Dose Intensity: Improving Cancer Treatment and Outcomes
Oncology Nursing Forum, 2005To determine the incidence of and reasons for chemotherapy dose delays or reductions.A performance improvement initiative formed the basis for a prospective nursing research study.A single institution in western Pennsylvania.204 patients scheduled for nonmyeloablative chemo-therapy.Data collection forms were completed by RNs and evaluated by an ...
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Journal of Chemotherapy, 2023
Relative dose intensity (RDI) has been associated with improved survival in patients with advanced solid tumours. However, there is no evidence regarding RDI in patients under long-term treatment with trabectedin for adult advanced soft tissue sarcoma (STS).
Yoshimasa Saito +8 more
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Relative dose intensity (RDI) has been associated with improved survival in patients with advanced solid tumours. However, there is no evidence regarding RDI in patients under long-term treatment with trabectedin for adult advanced soft tissue sarcoma (STS).
Yoshimasa Saito +8 more
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Relative dose intensity reduction in breast cancer adjuvant chemotherapy.
Cancer Research, 2009Abstract Abstract #4111 Introduction
 In breast cancer (BC), adjuvant chemotherapy has become a standard therapy, resulting in prolonged survival. This goal might be affected by chemotherapy dose reductions and delays that are not uncommon features.
 The aim of this study was to assess relative dose ...
C Faustino +4 more
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