Results 61 to 70 of about 3,054,956 (233)

Constrained relative entropy minimization with applications to multitask learning [PDF]

, 2013
textThis dissertation addresses probabilistic inference via relative entropy minimization subject to expectation constraints. A canonical representation of the solution is determined without the requirement for convexity of the constraint set, and is ...
Koyejo, Oluwasanmi Oluseye
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Relative Entropy and Variational Properties of Generalized Gibbsian Measures [PDF]

, 2004
We study the relative entropy density for generalized Gibbs measures. We first show its existence and obtain a familiar expression in terms of entropy and relative energy for a class of “almost Gibbsian measures” (almost sure continuity of conditional ...
Ny, Arnaud Le,, Külske, Christof, Redig, F.H.J., Le Ny, Arnaud, Redig, Frank,, Redig, FHJ Frank, Le Ny, A., Redig, Frank, Külske, C., Külske, Christof,, Le Ny, A, Külske, C, Ny, Arnaud Le   +12 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Statistical properties of mean relative entropy and its applications

Statistical Theory and Related Fields
A fundamental concept in information theory is information entropy, which is used to quantify the degree of uncertainty associated with random variables.
Lei Huang, Danting Wang, Lanpeng Ji
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Complete positivity order and relative entropy decay

Forum of Mathematics, Sigma
We prove that for a GNS-symmetric quantum Markov semigroup, the complete modified logarithmic Sobolev constant is bounded by the inverse of its complete positivity mixing time.
Li Gao, Marius Junge, Nicholas LaRacuente, Haojian Li   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multiscale Interactions betweenWater and Carbon Fluxes and Environmental Variables in A Central U.S. Grassland

Entropy, 2013
The temporal interactions between water and carbon cycling and the controlling environmental variables are investigated using wavelets and information theory.
Cassandra J. Wilson, Nathaniel A. Brunsell   +1 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source