Results 31 to 40 of about 8,766 (242)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On Relativized Minimality, memory and cue-based parsing [PDF]
, 2011 It is argued that Relativized Minimality (RM, Rizzi 1990 and Starke 2001, a.o.) is grammaticized as a real constraint that is functionally grounded as a response to memory.
Ortega Santos, Ivan
openaire +3 more sources
GlossaThis study outlines an auditory comprehension task of relative clauses with Argentine Spanish object-experiencer psychological (e.g., gustar ‘to like’) and activity (e.g., sonreír ‘to smile’) predicates.
Carolina Gattei +3 more
doaj +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Tier-based strict locality and the typology of agreement
Journal of Language ModellingThis paper presents a subregular analysis of syntactic agreement patterns modeled using command strings over Minimalist Grammar (MG) dependency trees (Graf and Shafiei 2019), incorporating a novel MG treatment of agreement.
Kenneth Hanson
doaj +1 more source
Glossa, 2017 Children with Specific Language Impairment (SLI) and children with Developmental Dyslexia (DD) have problems comprehending relative clauses (RCs) and find object RCs more difficult than subject RCs, as do typically developing children.
Bruna Molteni +4 more
doaj +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Comprehension of relative clauses by L2 learners of English: no asymmetry and puzzling prepositions [PDF]
Bucharest Working Papers in Linguistics, 2014 The asymmetry in processing subject and object relative clauses in first language acquisition has been the focus of interest of many researchers and has often been interpreted in terms of structural distance and Relativized Minimality.
Marie-Anne Duffeler, Martine Coene
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source