Results 51 to 60 of about 2,509 (238)

A usage based approach into the acquisition of relative clauses [PDF]

open access: yes, 2016
: Previous research has shown that cross-linguistically relative clauses are acquired late and are considered as a signal of linguistic complexity. This study adapts a usage-based account of relative clause acquisition in Turkish. A corpus based on three
Altan, Aslı, Altinkamis, Feyza
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tracking chains revisited

open access: yes, 2017
The structure ${\cal C}_2:=(1^\infty,\le,\le_1,\le_2)$, introduced and first analyzed in Carlson and Wilken 2012 (APAL), is shown to be elementary recursive.
Wilken, Gunnar
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Bounded time computation on metric spaces and Banach spaces

open access: yes, 2017
We extend the framework by Kawamura and Cook for investigating computational complexity for operators occurring in analysis. This model is based on second-order complexity theory for functions on the Baire space, which is lifted to metric spaces by means
Schröder, Matthias, Steinberg, Florian
core   +1 more source

Pemerolehan klausa relatif dalam kalangan kanak-kanak Melayu: satu kajian awal [PDF]

open access: yes, 2016
Kajian awal ini mengkaji perkembangan pemerolehan struktur sintaksis iaitu struktur klausa relatif dalam kalangan kanak-kanak Melayu di Lembah Klang. Objektif kajian adalah untuk menentukan kebolehan penggunaan struktur klausa relatif dalam kalangan ...
Lim, Hui Woan   +2 more
core   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The acquisition of object relative clauses in Spanish

open access: yesFrontiers in Communication
The aim of this paper is to compare children’s performance in a declarative object and subject relative comprehension task. Relativized Minimality proposes that object relative clauses are more difficult to process than subject relative clauses because ...
Vicenç Torrens
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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