Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Semantic Similarity Effects on Weak Islands Acceptability
, 2016 Two acceptability judgment experiments were conducted to investigate the role of similarity in weak islands environments. We tested predictions stemming from a narrow ap-proach to similarity (Featural Relativized Minimality) and from a broad approach to ...
Villata, Sandra, Franck, Julie
core
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Revisiting Subject-Object Asymmetry in the Production of Cantonese Relative Clauses: Evidence From Elicited Production in 3-Year-Olds. [PDF]
Front Psychol, 2021 Chan A +5 more
europepmc +1 more source
An Empirical Investigation of Featural Similarity in Wh-islands
According to the most recent version of Relativized Minimality, the ungrammaticality of weak islands is the result of featural similarity between elements in an intervention configuration. The theory posits that only features triggering movement have the
Villata, Sandra, Franck, Julie
core +1 more source
Minimality and (weighted) interpolation in Paley–Wiener spaces
, 2014 We investigate links between minimality, Carleson condition, and (weighted) interpolation in Paley-Wiener spaces. In particular, we show that the Carleson condition on a sequence.
Frédéric Gaunard, Gaunard, Frédéric,
core +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Hensel minimality: Geometric criteria for $\ell$-h-minimality [PDF]
Recently, Cluckers, Halupczok and Rideau-Kikuchi developed a new axiomatic framework for tame non-Archimedean geometry, called Hensel minimality. It was extended to mixed characteristic together with the author.
Vermeulen, Floris
core