Results 161 to 170 of about 24,582,015 (196)

Relaxin-2 expression in temporal bone carcinoma

European Archives of Oto-Rhino-Laryngology, 2014
Temporal bone squamous cell carcinoma (TBSCC) is an uncommon, aggressive malignancy with a significant local recurrence rate even in patients with postoperative pathology reports of free surgical margins. This raises the question of how "free" negative margins should be to be oncologically safe, especially in bone tissue. A potential role for relaxin-2
MARIONI, GINO, Zanoletti, Elisabetta, Lovato, Andrea, Franchella, S, Giacomelli, L, Gianatti, A, Mazzoni, A, BLANDAMURA, STELLA, MARTINI, ALESSANDRO   +8 more
openaire   +3 more sources

Serum relaxin-2 as a novel biomarker for prostate cancer

British Journal of Biomedical Science, 2018
Prostate cancer is a common neoplasia in men and its incidence continues to rise in many countries.
Y, Xu, Q, Yu, Y, Liu
openaire   +2 more sources

Commercial immunoassays for human relaxin-2

Molecular and Cellular Endocrinology, 2019
Several different immunoassays have been used in the commercial pharmaceutical development of serelaxin. These assays have been well validated for submission of GLP preclinical and clinical studies to the FDA and EU regulatory bodies. The requirements for these assays exceed that of most research assays commonly developed in academic research but have ...
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The plasma levels of relaxin-2 and relaxin-3 in patients with diabetes

Clinical Biochemistry, 2013
Relaxin-2 has been found to alleviate fibrosis in experimental diabetic cardiomyopathy. In addition, the levels of serum relaxin-3 were increased and correlated with all the component traits of metabolic syndrome. We investigated the levels of plasma relaxin-2 or relaxin-3 and their relationship to component traits in patients with diabetes.We studied ...
Xiaohui, Zhang, Minling, Zhu, Meng, Zhao, Wenjia, Chen, Yu, Fu, Yue, Liu, Wenxiu, Liu, Bo, Zhang, Xinhua, Yin, Bing, Bai   +9 more
openaire   +2 more sources

Autoregulation of human relaxin-2 gene expression critically involves relaxin and glucocorticoid receptor binding to glucocorticoid response half-sites in the relaxin-2 promoter

Regulatory Peptides, 2009
Relaxin peptides act in brain, reproductive and cardiovascular systems, kidneys, and connective tissue through different G protein-coupled receptors. We reported that human relaxin-2 and porcine relaxin are both agonists at the human glucocorticoid receptor (GR).
Thomas, Dschietzig, Cornelia, Bartsch, Silja, Wessler, Gert, Baumann, Karl, Stangl   +4 more
openaire   +2 more sources

B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin)

European Journal of Pharmacology, 2017
Recombinant H2 relaxin (serelaxin) has gained considerable attention as a new vasoprotective drug, largely due to its potential therapeutic effects in heart failure and fibrosis. However, serelaxin is laborious and costly to produce. A single-chain peptidomimetic, B7-33, has been developed to overcome these problems but little is known about its ...
Sarah A, Marshall, Kelly, O'Sullivan, Hooi Hooi, Ng, Ross A D, Bathgate, Laura J, Parry, Mohammed Akhter, Hossain, Chen Huei, Leo   +6 more
openaire   +2 more sources

Prognostic association of circulating relaxin-2 in acute heart failure

International Journal of Cardiology
Despite the increasing interest in the study of the endogenous relaxin system in heart failure (HF), its role as a prognostic marker in acute HF remains unclear. We aimed to evaluate the association of relaxin-2 circulating levels with 6 months' mortality in acute HF.We evaluated relaxin-2 serum levels at admission in a cohort of patients with acute HF
Mariana, Pintalhao, Francisco, Vasques-Nóvoa, António S, Barros, Patrícia, Lourenço, Benedita, Couto-Viana, Adelino, Leite-Moreira, Paulo, Bettencourt, Paulo, Castro-Chaves   +7 more
openaire   +2 more sources

The Roles of the A- and B-Chains of Human Relaxin-2 and -3 on Their Biological Activity

Current Protein & Peptide Science, 2010
Two members of the human insulin/relaxin superfamily, relaxins-2 and 3 (H2 and H3 respectively), are separated by nearly 75 years in terms of chronological identification but are both the subject of intense recent biological study. The physiological effects of H2 relaxin include vasodilatory, anti-inflammatory, extracellular matrix remodeling, and ...
Mohammed Akhter, Hossain, John D, Wade
openaire   +2 more sources

Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs

Bioconjugate Chemistry, 2018
Peptide hormone relaxin-2, a member of the insulin family of peptides, plays a key role in hemodynamics and renal function and has shown preclinical efficacy in multiple disease models, including acute heart failure, fibrosis, preeclampsia, and corneal wound healing.
Avinash Muppidi, Sang Jun Lee, Che-Hsiung Hsu, Huafei Zou, Candy Lee, Elsa Pflimlin, Madhupriya Mahankali, Pengyu Yang, Elizabeth Chao, Insha Ahmad, Andreas Crameri, Danling Wang, Ashley Woods, Weijun Shen   +13 more
openaire   +2 more sources

The Role of Relaxin-2 in Tissue Remodeling of Chronic Rhinosinusitis With Nasal Polyps

American Journal of Rhinology & Allergy, 2019
Background Relaxin is a small peptide hormone that regulates extracellular matrix remodeling and reduces fibrosis in a number of organs. Little is known about its impact on chronic rhinosinusitis with nasal polyps (CRSwNP); thus, we aimed to determine the expression of human H2 relaxin (relaxin-2) and its role ...
Yimin, Li, Guojing, Tan, Jie, Liu, Xia, Ke, Yang, Shen, Jiangju, Huang, Guohua, Hu, Tingxiu, Xiang, Yucheng, Yang   +8 more
openaire   +2 more sources