Results 41 to 50 of about 569,644 (316)

TRH: Pathophysiologic and clinical implications [PDF]

, 1985
Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin.
Pickardt, C. R., Scriba, Peter Christian
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A   +12 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identification of a novel corticotropin-releasing hormone type 1 beta-Like receptor variant lacking exon 13 in human pregnant myometrium regulated by estradiol-17 beta and progesterone [PDF]

, 2010
Two types of CRH receptors mediate the diverse biological functions of CRH and CRH-related peptides. The type 1 CRH-R (CRH-R1) is extensively targeted by pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Jing Chen, Emmanouil Karteris, Markovic, Danijela, Grammatopoulos, DK, Danijela Markovic, Edward W. Hillhouse, Grammatopoulos, Dimitris, Hillhouse, EW, Chen, J, Karteris, Emmanouil, Dimitris K. Grammatopoulos, Markovic, D, Hillhouse, Edward W., Chen, Jing   +13 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Research progress of manganese exposure on abnormal GnRH release in hypothalamus affecting reproductive function

环境与职业医学, 2023
Manganese plays an important physiological role in the organism, and excessive manganese exposure can cause impairment of neurological and reproductive functions.
Huan MAO, Yan LI
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin

, 2013
There remains a critical need for new therapeutics that promote wound healing in patients suffering from chronic skin wounds. This is, in part, due to a shortage of simple, physiologically and clinically relevant test systems for investigating candidate ...
Paredes Roberto, Matthias Augustin, Jennifer E Kloepper, Amaya, Enrique; id_orcid, Roberto Paredes (452874), Pattwell David M., Natalia T. Meier (452870), Enrique Amaya, Matthias Augustin (452876), Haslam Iain S., Augustin Matthias, Paus Ralf, Hardman, Matthew J, Kloepper, Jennifer E, Paus, Ralf, Sebastian Debus, Pattwell, David M., Wolfgang Funk, Matthew J Hardman, Wolfgang Funk (405807), Kloepper Jennifer E., Meier Natalia T., Matthew J. Hardman (452878), Amaya, Enrique, Zhang, Guo You, Amaya Enrique, Debus, Sebastian, Zhang Guo-You, Vladimir Emelianov (452873), Jennifer E. Kloepper (452877), Paredes, Roberto, Emelianov Vladimir, Guo-You Zhang, Sebastian Debus (452875), Hardman Matthew J., Haslam, Iain S., Funk Wolfgang, Hardman, Matthew J., Augustin, Matthias, Pattwell, David M, Kloepper, Jennifer E., Haslam, Iain S, Enrique Amaya (31703), Ralf Paus (261703), Emelianov, Vladimir, Haslam, Iain, Zhang, Guo-You, Natalia T Meier, Debus Sebastian, Meier, Natalia T., Vladimir Emelianov, Iain S Haslam, Roberto Paredes, David M. Pattwell (452872), Ralf Paus, Meier, Natalia T, Guo-You Zhang (397743), Funk, Wolfgang, Iain S. Haslam (452871), David M Pattwell   +59 more
core   +1 more source