Results 81 to 90 of about 27,916,807 (331)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Numerical Permeation Models to Predict the Annulus Composition of Flexible Pipes
Journal of Marine Science and EngineeringThe migration of acid gases through the pressure sheath of flexible pipes may induce a corrosive environment that can lead to steel armors’ failure by SCC (stress corrosion cracking).
João Marcos B. Vieira +1 more
doaj +1 more source
A new adaptive response surface method for reliability analysis [PDF]
, 2013 Response surface method is a convenient tool to assess reliability for a wide range of structural mechanical problems. More specifically, adaptive schemes which consist in iteratively refine the experimental design close to the limit state have received ...
Petitjean, Frank +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Macromolecular Materials and EngineeringDevelopment of fifth‐generation technology leads to a growing demand for materials with exceptional thermal property, mechanical strength, and low dielectric loss. However, ensuring the broad application of such materials by comprehensively investigating
Peijiang Liu +9 more
doaj +1 more source
Creep-rupture reliability analysis [PDF]
A probabilistic approach to the correlation and extrapolation of creep-rupture data is presented. Time temperature parameters (TTP) are used to correlate the data, and an analytical expression for the master curve is developed.
Peralta-Duran, A., Wirsching, P. H.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Fatigue Reliability Optimization for Three-Axle Bogie Frame Based on Response Surface Method
机车电传动, 2021 The three-axle bogie frame was taken as the research object, the reliability analysis for structural strength and fatigue life of the key welds were carried out.
Xinli HAN, Yuehua GAO
doaj
Computation-based reliability analysis [PDF]
The structural and functional complexity of man-made systems is reported, showing the reliability analysis task becoming much more complex. Quantative methods are discussed for analyzing system quality.
Meyer, J. F.
core +1 more source
System reliability analysis through corona testing [PDF]
A corona vacuum test facility for nondestructive testing of power system components was built in the Reliability and Quality Engineering Test Laboratories at the NASA Lewis Research Center. The facility was developed to simulate operating temperature and
Koutnik, E. A. +2 more
core +2 more sources