Results 61 to 70 of about 33,732 (139)

Investigation of Teratogenic Concerns in the Coronavirus Disease of 2019 Era

Birth Defects Research, Volume 118, Issue 2, February 2026.
ABSTRACT Background MotherToBaby (MTB) is a teratogen information service that provides information about exposures during pregnancy and breastfeeding to the public and healthcare providers. During the Coronavirus Disease of 2019 (COVID‐19) pandemic, MTB received an influx of queries regarding the teratogenicity of the virus and the vaccine.
Kate Richardson, Emily C. Daykin, Kathleen Shields, S. Shahrukh Hashmi, Lorrie Harris‐Sagaribay, Molly Daniels, Myla Ashfaq   +6 more
wiley   +1 more source

CD56bright NK cells are negatively associated with antibody response to vaccination in people with multiple sclerosis on B‐cell‐depleting therapy

Clinical &Translational Immunology, Volume 15, Issue 2, 2026.
Antibody response to vaccination in people with multiple sclerosis receiving B‐cell depletion therapy is associated with B‐cell frequency but not time since B‐cell depletion. Immunoregulatory CD56bright NK cells may negatively impact antibody responses in this group.
Griffith B Perkins, Christopher M Hope, Cheng Sheng Chai, Matthew J Tunbridge, Sebastian Sterling, Kevin Webb, Joey Yap, Arthur Eng Lip Yeow, Makutiro G Masavuli, Jacqueline Scaffidi, James D Zuiani, Anouschka Akerman, Anupriya Aggarwal, Vanessa Milogiannakis, Matthew B Roberts, Plinio R Hurtado, Stuart Turville, Branka Grubor‐Bauk, Simon C Barry, Janakan Ravindran, Patrick Toby Coates, Pravin Hissaria   +21 more
wiley   +1 more source

The Impact of COVID‐19 on Obstructive Pulmonary Diseases: A Narrative Review of Long‐Term Consequences and Vaccination Strategies

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims The COVID‐19 pandemic has posed significant challenges for individuals with obstructive pulmonary diseases (OPDs), such as asthma and chronic obstructive pulmonary disease (COPD). Emerging evidence highlights the complex interplay between SARS‐CoV‐2 infection and OPDs, including increased risks of severe disease, long‐term ...
Behnam Dalfardi, Hamidreza Abtahi, Maryam Edalatifard, Sedigheh Mozaffari, Besharat Rahimi, Ghazal Roostaei, Niloofar Khoshnam Rad   +6 more
wiley   +1 more source

Exacerbations and Management of Asthma in Viral Lower Respiratory Tract Infections: The Significance of Immunoglobulin E

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Viral‐respiratory infections are the most prevalent illness among humans. A viral infection affecting lower respiratory tract infections (LRTI) is a critical health concern worldwide. The COVID‐19 pandemic has significantly impacted respiratory health, particularly in individuals with asthma.
Mandana Akhavan, Parastoo Yousefi, Alireza Tabibzadeh   +2 more
wiley   +1 more source

Effects of Siltuximab Versus Corticosteroids in Preventing COVID−19 Pneumonia Disease Progression: Multicentre, Open‐Label, Randomized Clinical Trial

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT In 2020, COVID‐19 caused a global health crisis, prompting research efforts and accelerating drug development. As part of this response, we conducted a phase 2b, multicentre, open‐label, randomized (1:1) clinical trial to compare the effects of siltuximab versus corticosteroids on disease progression in hospitalized adults with COVID‐19 ...
Lorna Leal, María del Puerto Bernoy González, Clara Castán, Fernanda Meira, Gerard Dueñas, Judit Pich, Marta Hernández‐Meneses, Verónica Rico, Nicole García‐Pouton, Daiana Agüero, Elisa de Lazzari, Adrià Tomé, Sabina Herrera, José Muñóz, Alex Almuedo, Sergio Prieto‐González, Pedro Castro, Maria Angeles Marcos, Montse Tuset, Roger Paredes, Cristina Carbonell, David Dalmau, José Antonio Martínez, Alex Soriano, Felipe García, SILCOR study group, A. Moreno, M. Solá, A. Ugarte, A. Gonzalez‐Cordón, M. Laguno, J. Rojas, B. Torres, J. Ambrosioni, L. Morata, C. García‐Vidal, C. Cardozo, M. Bodro, M. Chumbita, L. de la Mora, A. Inciarte, P. Puerta‐Alcalde, A. del Rio, S. Fernandez, A. Tellez, D. Camprubi, M. T. de Alba, M. Fernandez, E. Ferrer, B. Grau, H. Marti, M. Muelas, M. J. Pinazo, N. Rodriguez, A. Aldea, J. Calvo, A. Capdevila, I. Carbonell, A. Foncillas, M. Feliu, C. Gabara, I. Grafia, A. Ladino, A. López‐Soto, A. Matas, J. Marco‐Hernández, P. Moreno, J. Naval, J. Padrosa, M. Pellicé, J. Ribot, O. Rodríguez‐Núnez, F. Seguí, H. Ventosa, C. Zamora‐Martínez, M. Alvarez, E. Rubio, A. Vergara   +77 more
wiley   +1 more source

Assessing the effect of remdesivir alone and in combination with corticosteroids on time to death in COVID-19: A propensity score-matched analysis

Journal of Clinical Virology Plus
Background: This study aimed to evaluate the impact of remdesivir, alone or in combination with corticosteroids, on the time to death in COVID-19 patients. Methods: This retrospective cohort study was conducted between March 20, 2020, and March 18, 2021,
Mohamad Amin Pourhoseingholi, Mehdi Azizmohammad Looha, Saba Ilkhani, Hamidreza Hatamabadi, Amir Sadeghi, Seyed Amir Ahmad Safavi-Naini, Kamran Heidari, Nazanin Taraghikhah, Mohammad Mahdi Fallah, Reyhaneh Kalantar, Nariman Naderi, Romina Esbati, Nastaran Ebrahimi, Ali Solhpour, Tannaz Jamialahmadi, Amirhossein Sahebkar   +15 more
doaj   +1 more source

The impact of remdesivir on renal and liver functions in severe COVID-19 patients with presence of viral load

Scientific Reports
The impact of remdesivir on renal and liver functions remains a matter of concern in advanced COVID-19 patients with high illness severity and presence of viral load.
Petr Waldauf, Ivana Jurisinova, Eva Svobodova, Michaela Diblickova, Tomas Tencer, Jan Zavora, Gabriela Smela, Lenka Kupidlovska, Vaclava Adamkova, Marta Fridrichova, Karolina Jerabkova, Jakub Mikes, Frantisek Duska, Ladislav Dusek, Martin Balik   +14 more
doaj   +1 more source

Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6

Journal of Translational Medicine
Background Atherosclerosis is characterized by complex pathological processes, including endothelial dysfunction and inflammation. The underlying pathogenic mechanisms have been well elucidated; however, effective treatments are yet to be validated.
Hanning Zhang, Ruru Li, Qianqian Huo, Li Li, Min Li, Shunxin Hu, Changjie Ren, Zongyin Wu, Chenghu Zhang   +8 more
doaj   +1 more source

SARS-CoV-2 Remdesivir Exposure Leads to Different Evolutionary Pathways That Converge in Moderate Levels of Drug Resistance

Viruses
Various SARS-CoV-2 remdesivir resistance-associated substitutions (RAS) have been reported, but a comprehensive comparison of their resistance levels is lacking.
Carlota Fernandez-Antunez, Line A. Ryberg, Kuan Wang, Long V. Pham, Lotte S. Mikkelsen, Ulrik Fahnøe, Katrine T. Hartmann, Henrik E. Jensen, Kenn Holmbeck, Jens Bukh, Santseharay Ramirez   +10 more
doaj   +1 more source

The impact of remdesivir on SARS-CoV-2 evolution in vivo

JCI Insight
The impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo has remained unclear. In this single-center, retrospective cohort study, we assessed SARS-CoV-2 diversification and diversity over time in a cohort of hospitalized patients who did or
Ted Ling-Hu, Lacy M. Simons, Estefany Rios-Guzman, Alexandre Machado Carvalho, Maria Francesca R. Agnes, Arghavan Alisoltanidehkordi, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist   +8 more
doaj   +1 more source