Results 61 to 70 of about 32,071 (158)

Rapid Response to Remdesivir in Hospitalised COVID-19 Patients: A Propensity Score Weighted Multicentre Cohort Study

Infectious Diseases and Therapy, 2023
Introduction Remdesivir is a registered treatment for hospitalised patients with COVID-19 that has moderate clinical effectiveness. Anecdotally, some patients’ respiratory insufficiency seemed to recover particularly rapidly after initiation of ...
Emiel Leegwater, Lisa Dol, Menno R. Benard, Eveline E. Roelofsen, Nathalie M. Delfos, Machteld van der Feltz, Femke P. N. Mollema, Liesbeth B. E. Bosma, Loes E. Visser, Thomas H. Ottens, Nathalie D. van Burgel, Sesmu M. Arbous, Lahssan H. El Bouazzaoui, Rachel Knevel, Rolf H. H. Groenwold, Mark G. J. de Boer, Leo G. Visser, Frits R. Rosendaal, Erik B. Wilms, Cees van Nieuwkoop   +19 more
doaj   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Medical countermeasures during public health emergencies—Does information sharing among health system coalition help?

Decision Sciences, EarlyView.
Abstract Challenged by constrained healthcare resources, hospitals encounter barriers to accommodating patient demand during public health emergencies. Building on a comprehensive literature review of information and knowledge exchange in healthcare, disaster management, and humanitarian operations management, this study explores the influence of ...
Sukrit Pal, Anand Nair
wiley   +1 more source

Variation in clinical presentation, complications and outcomes for Māori and Pacific peoples among hospitalised adults with COVID‐19 in 2022, Aotearoa New Zealand

Internal Medicine Journal, EarlyView.
Abstract Background Pacific region‐specific data on the clinical course of COVID‐19 are limited. We aimed to describe clinical features and outcomes from Aotearoa New Zealand patients, focusing on Māori and Pacific peoples. Methods We conducted a retrospective cohort study among adults (≥16 years) hospitalised due to COVID‐19 at 11 hospitals from ...
Michael J. Maze, Haylea Rodgers, Jonathan Williman, Rebekah Anstey, Emma Best, Hasan Bhally, Aliya Bryce, Catherina Chang, Kevin Chen, Jack Dummer, Michael Epton, William Good, Jennifer Goodson, Corina Grey, Kate Grimwade, Robert J. Hancox, Redzuan Hassan, Thomas Hills, Sandra Hotu, Colin McArthur, Susan Morpeth, David R. Murdoch, Fiona Pease, Romana Pylypchuk, Nigel Raymond, Stephen Ritchie, Deborah Ryan, Vanessa Selak, Malina Storer, Tony Walls, Rachel Webb, Conroy Wong, Karen Wright   +32 more
wiley   +1 more source

Effect of remdesivir on mortality and the need for mechanical ventilation among hospitalized patients with COVID-19: real-world data from a resource-limited country

International Journal of Infectious Diseases, 2023
Objectives: Georgia introduced remdesivir for the treatment of COVID-19 in December 2020. We evaluated the real-world effect of remdesivir on mortality and the need for mechanical ventilation among inpatients with COVID-19.
Revaz Metchurtchlishvili, Nikoloz Chkhartishvili, Akaki Abutidze, Marina Endeladze, Marine Ezugbaia, Ana Bakradze, Tengiz Tsertsvadze   +6 more
doaj  

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source

Point‐of‐Care Testing by Multiplex‐PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation—Results of a Prospective Study

Transplant Infectious Disease, EarlyView.
Use of POCtmPCR with noninvasive samples (NPS and sputum) in LTx recipients with viral LRTI are a viable alternative to invasive BAL sampling, ABSTRACT Background Respiratory tract infections (RTIs) are a leading cause of morbidity and mortality following lung transplantation (LTx).
Susanne Simon, Merle Sophie Kaiser, Marcus Bachmann, Gérard Krause, Jens Gottlieb   +4 more
wiley   +1 more source

Precipitating factors of bradycardia after remdesivir administration: ICU admission and cutoff value for declining heart rate

Journal of Microbiology, Immunology and Infection, 2023
Background: Despite increasing concerns about the association between remdesivir and bradycardia in severe coronavirus disease 2019 (COVID-19) patients receiving remdesivir, information on its clinical course and precipitating factors is limited. Our aim
Yan-Zuo Chen, Ming-Shen Lin, Yi-Ping Lin, Yi-Zhan Liu, Chia-Jui Yang   +4 more
doaj  

Longitudinal Innate and Heterologous Adaptive Immune Responses to SARS‐CoV‐2 JN.1 in Transplant Recipients With Prior Omicron Infection: Limited Neutralization but Robust CD4+ T‐Cell Activity

Transplant Infectious Disease, EarlyView.
In transplant recipients with prior Omicron infection, neutralizing antibodies against JN.1 were limited and often absent 1 year later. However, robust and durable CD4⁺ T‐cell responses were consistently observed, suggesting that cellular immunity may offer sustained protection against emerging SARS‐CoV‐2 variants, despite modest antibody responses ...
Victor H. Ferreira, Brandon Keith, Faranak Mavandadnejad, Alejandro Ferro, Sara Marocco, Golnaz Amidpour, Alexandra Kurtesi, Freda Qi, Anne‐Claude Gingras, Victoria G. Hall, Deepali Kumar, Atul Humar   +11 more
wiley   +1 more source

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Nature Communications, 2021
Remdesivir is a nucleoside analog that inhibits the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and is used as a drug to treat COVID19 patients. Here, the authors provide insights into the mechanism of remdesivir-induced RdRp stalling by determining ...
Goran Kokic, Hauke S. Hillen, Dimitry Tegunov, Christian Dienemann, Florian Seitz, Jana Schmitzova, Lucas Farnung, Aaron Siewert, Claudia Höbartner, Patrick Cramer   +9 more
doaj   +1 more source