Results 61 to 70 of about 34,432 (188)

A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials [PDF]

arXiv, 2020
COVID-19 has fast-paced drug re-positioning for its treatment. This work builds computational models for the same. The aim is to assist clinicians with a tool for selecting prospective antiviral treatments. Since the virus is known to mutate fast, the tool is likely to help clinicians in selecting the right set of antivirals for the mutated isolate ...
arxiv  

Effect of remdesivir on mortality and the need for mechanical ventilation among hospitalized patients with COVID-19: real-world data from a resource-limited country

International Journal of Infectious Diseases, 2023
Objectives: Georgia introduced remdesivir for the treatment of COVID-19 in December 2020. We evaluated the real-world effect of remdesivir on mortality and the need for mechanical ventilation among inpatients with COVID-19.
Revaz Metchurtchlishvili, Nikoloz Chkhartishvili, Akaki Abutidze, Marina Endeladze, Marine Ezugbaia, Ana Bakradze, Tengiz Tsertsvadze   +6 more
doaj  

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, EarlyView.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Ratifying the efficacy and safety of intensive induction chemotherapy for acute myeloid leukaemia by the Australasian Leukaemia & Lymphoma Group consensus approach

Internal Medicine Journal, EarlyView.
Abstract Background After pharmaceutical benefits scheme approval of midostaurin for fms‐like tyrosine kinase 3 (FLT3)‐mutated acute myeloid leukaemia (AML) in 2018, the Australasian Leukaemia & Lymphoma Group (ALLG) proposed a consensus approach to AML induction with 7+3 chemotherapy (7 days of infusional cytarabine with three doses of anthracycline ...
Aditya Tedjaseputra, Amanda Tey, Anastasios Nalpantidis, George Grigoriadis, Shaun Fleming, Shahla Vilcassim, Pasquale L. Fedele, Michael Sze Yuan Low, Paul Yeh, Michael Gilbertson, Ashwini Bennett, Gareth P. Gregory, Danielle Oh, Donna Gairns, Zane Kaplan, Sanjeev D. Chunilal, Susan Brown, Stephen Opat, Chong C. Chua, Jake Shortt   +19 more
wiley   +1 more source

Precipitating factors of bradycardia after remdesivir administration: ICU admission and cutoff value for declining heart rate

Journal of Microbiology, Immunology and Infection, 2023
Background: Despite increasing concerns about the association between remdesivir and bradycardia in severe coronavirus disease 2019 (COVID-19) patients receiving remdesivir, information on its clinical course and precipitating factors is limited. Our aim
Yan-Zuo Chen, Ming-Shen Lin, Yi-Ping Lin, Yi-Zhan Liu, Chia-Jui Yang   +4 more
doaj  

Pharmacokinetics of GS‐441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021–2024)

Journal of Small Animal Practice, EarlyView.
Objectives This study aimed to: (1) characterise the pharmacokinetics of GS‐441524 following intravenous (iv) administration of 15 mg/kg remdesivir (RDV) in client‐owned cats with feline infectious peritonitis (FIP); (2) document plasma protein binding of GS‐441524 in cats; (3) determine whether trough GS‐441524 plasma concentrations predict ‘simple ...
S. J. Coggins, M. Govendir, J. M. Norris, R. Malik, E. J. Hall, M. F. Thompson, B. Kimble   +6 more
wiley   +1 more source

Cochrane's COVID‐19 Living Systematic Reviews: A Mixed‐Methods Study of Their Conduct, Reporting and Currency

Cochrane Evidence Synthesis and Methods, Volume 3, Issue 3, May 2025.
ABSTRACT Background Living systematic reviews (LSRs) should provide up‐to‐date evidence for priority questions where the evidence may be uncertain and fast‐moving. LSRs featured prominently during COVID‐19 and formed part of Cochrane's response to the pandemic.
Kevindu De Silva, Tari Turner, Steve McDonald   +2 more
wiley   +1 more source

Efficacy of Remdesivir in Covid-19 Patients; Multicenter Study in Lahore [PDF]

, 2020
Najeeb Ullah, Khurshid Khan, Javeid Iqbal, Asım Noor Rana, Bilal Bin Younis, Mohsin Asif, Aijaz Zeeshan Khan Chachar, Falak shan   +7 more
openalex   +1 more source

Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis [PDF]

, 2020
Matthew R Davis, Christine Pham, Jeffrey J. Cies   +2 more
openalex   +1 more source

Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS‐CoV‐2 Infection

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The concept of macrophage polarization has been largely used in human diseases to define a typology of activation of myeloid cells reminiscent of lymphocyte functional subsets. In COVID‐19, several studies have investigated myeloid compartment dysregulation and macrophage polarization as an indicator of disease prognosis and monitoring.
Soraya Mezouar, Jean‐Louis Mege
wiley   +1 more source