A study of effect of remdesivir on mortatlity and hospital stay of moderate to severe cases of COVID-19/ severe acute respiratory illness in North Karnataka region [PDF]
Al Ameen Journal of Medical Sciences, 2021 Background: As the epidemic that started at Wuhan spread globally many agents with antiviral activity were evaluated for the treatment of coronavirus disease. Many agents were claimed to be “Game changer” in the management of covid.
Habibulla D. Attar +4 more
doaj
Covid-19: Selected NHS patients will be treated with remdesivir [PDF]
, 2020 Zosia Kmietowicz
openalex +1 more source
Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models
Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario +2 more
wiley +1 more source
Remdesivir and its antiviral activity against COVID-19: A systematic review
Clinical Epidemiology and Global Health, 2021 Background: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. Methods: Available publications were systematically explored on some databases and gray literature was examined.
Andri Frediansyah +4 more
doaj
Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon
Advanced Therapeutics, Volume 8, Issue 4, April 2025.Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap +10 more
wiley +1 more source
Data Monitoring for the Chinese Clinical Trials of Remdesivir in Treating Patients with COVID-19 During the Pandemic Crisis [PDF]
, 2020 Weichung Joe Shih, Chen Yao, Tai Xie
openalex +1 more source
Advanced Science, Volume 12, Issue 15, April 17, 2025.Azvudine shows benefits in reducing all‐cause mortality in hospitalized SARS‐CoV‐2 infected patients and liver diseases. COVID‐19 patients with kidney disease and without autoimmune diseases show a preference for azvudine. Azvudine may be a promising antiviral agent for treating COVID‐19 concomitant with liver diseases.
Junyi Sun +18 more
wiley +1 more source
T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection
Advanced Science, Volume 12, Issue 15, April 17, 2025.This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu +8 more
wiley +1 more source
Case Reports in Women's Health, 2020 Summary: Remdesivir is a novel therapeutic with known activity against SARS CoV-2 and related coronaviruses. Remdesivir, as well as convalescent plasma therapy, are currently under investigation as potential therapies for patients with Coronavirus ...
Jonathon Anderson +3 more
doaj
A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery
Advanced Science, Volume 12, Issue 16, April 24, 2025.Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye +10 more
wiley +1 more source