Results 61 to 70 of about 4,685 (255)

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, Volume 13, Issue 23, 23 April 2026.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Exploring the Utility of remimazolam in cesarean sections under general anesthesia: A preliminary retrospective analysis and Implications for future study

Heliyon
Background: Remimazolam has recently been introduced as a maintenance agent for general anesthesia. However, the effect of remimazolam on peripartum prognosis has not been reported.
Eunji Ko, Sung Uk Choi, Jaehee Lee, Eun-Saem Choi, Yoon Sun Park   +4 more
doaj   +1 more source

Emerging horizons in anaesthetic practice: a pharmacological update [PDF]

, 2018
Anesthesiologists are in search for new drugs possessing properties like rapid onset of action, minimal residual effects, better hemodynamic stability, organ independent metabolism and cost effective.
Codi, R. Sudar, Manimekalai, K.
core   +2 more sources

Investigation of the actual implementation of “post‐sedation discharge criteria” and “time‐out” immediately before procedure in endoscopy: A nationwide survey study in Japan

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Post‐sedation discharge criteria for outpatient endoscopy and time‐out procedures immediately before endoscopic examinations are important for ensuring patient safety. This study used a web‐based questionnaire to survey the implementation status and current situation of these practices in Japan in 2024.
Atsushi Imagawa, Motohiko Kato, Junko Koyama, Mitsuhiro Fujishiro   +3 more
wiley   +1 more source

Two cases of circulatory collapse due to suspected remimazolam anaphylaxis

JA Clinical Reports, 2022
Background Remimazolam was approved in Japan in January 2020. We report two cases of circulatory collapse due to suspected remimazolam anaphylaxis during anesthetic induction. Case presentation Case 1: A 74-year-old male was scheduled for debridement and
Satoshi Uchida, Daiki Takekawa, Masato Kitayama, Kazuyoshi Hirota   +3 more
doaj   +1 more source

Influence of remifentanil on the pharmacokinetics and pharmacodynamics of remimazolam in healthy volunteers [PDF]

Background: Synergistic effects between opioids and remimazolam on bispectral index (BIS) and modified observer’s assessment of alertness and/or sedation (MOAAS) score were previously described.
Colin, Pieter, Eleveld, Douglas J., Koomen, Jeroen V., Pesic, Marija, Struys, Michel M.R.F., Stöhr, Thomas, Vellinga, Remco   +6 more
core   +1 more source

When Endoscopic Sedation is Not an Option: Insights From a Multicenter on‐site Survey on Tolerance for Japanese Gastric Cancer Screening

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Esophagogastroduodenoscopy (EGD) is widely used for gastric cancer (GC) screening in Japan; however, sedation during EGD is not recommended. We aimed to assess the tolerability of unsedated EGD (USEGD) in the Japanese population. Methods Participants who underwent GC screening in Japanese urban areas between July 2021 and December ...
Kazuya Inoki, Toshiya Chiba, Kazuhiro Miura, Teppei Tagawa, Yutaka Aoyagi, Yoshiaki Takeuchi, Naoya Moriyama, Kensuke Kuraoka, Tadashi Ohara, Yuko Haruhara, Akira Mizuki, Jun Satio, Yoshimi Hagisawa, Naomi Ono, Noboru Takayama, Takeo Onishi, Akira Mishima, Norihiro Suzuki, Kazuo Kikuchi, Atsushi Katagiri, Fuyuhiko Yamamura, Sachiko Ohde, Eisuke Inoue, Takahisa Matsuda, Hitoshi Yoshida   +24 more
wiley   +1 more source

Doctor of Philosophy [PDF]

, 2016
dissertationThe goal of this study was to investigate the bioavailability, efficacy, and safety of inhaled remifentanil, inhaled remimazolam, and combinations of both drugs in mouse, rat, and pig models.
Bevans, Tatjana S.
core  

Adverse Events of Single Balloon Enteroscopy‐assisted Endoscopic Retrograde Cholangiopancreatography in the Elderly: A Propensity Score Matching Analysis

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background Sedation for conventional endoscopic retrograde cholangiopancreatography (ERCP) has been reported to be safe even for elderly patients. However, the safety of sedation for balloon enteroscopy‐assisted ERCP (BE‐ERCP) has not been well‐studied in the elderly.
Hiroki Nakagawa, Tsuyoshi Takeda, Takeshi Okamoto, Takafumi Mie, Takaaki Furukawa, Takashi Sasaki, Masato Ozaka, Takahisa Matsuda, Yoshinori Igarashi, Naoki Sasahira   +9 more
wiley   +1 more source

Comparative analysis of the effect of electromyogram to bispectral index and 95% spectral edge frequency under remimazolam and propofol anesthesia: a prospective, randomized, controlled clinical trial [PDF]

, 2023
BackgroundBispectral index (BIS), an index used to monitor the depth of anesthesia, can be interfered with by the electromyogram (EMG) signal. The 95% spectral edge frequency (SEF95) also can reflect the sedation depth.
Aijun Xu, Cheng Liu, Li Ma, Miao Ma, Tianli Xie, Tiantian Chu, Yueyang Xin, Yuhui Liang   +7 more
core   +1 more source