Results 61 to 70 of about 4,916 (258)

Remimazolam attenuated lipopolysaccharide-induced behavioral deficits and neuronal injury via activation of the Nrf2 pathway

Scientific Reports
Sepsis is a severe disorder that is always accompanied by brain injury and dysfunction. This study aimed to evaluate the effects of remimazolam, a new ultra-short-acting sedative, on LPS-induced neuronal injury, and the role of Nrf2 signaling pathway ...
Yi Wei, Sining Pan, Zhan Zhou, Ying Yang, Tianxiao Liu, Jing Chen, Yubo Xie   +6 more
doaj   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Effect of remimazolam on intraoperative hemodynamic stability in patients undergoing cerebrovascular bypass surgery: a prospective randomized controlled trial

Korean Journal of Anesthesiology
Background Maintenance of stable blood pressure (BP) during cerebrovascular bypass surgery is crucial to prevent cerebral ischemia. We compared the effect of remimazolam anesthesia with that of propofol-induced and desflurane-maintained anesthesia on ...
Chang-Hoon Koo, S. Lee, H. Kim, Soowon Lee, Y. Bae, Ah-Young Oh, Young-Tae Jeon, Jung-Hee Ryu   +7 more
semanticscholar   +1 more source

The Effect of Remimazolam Administration on Emergence Delirium in Children After General Anesthesia: A Systematic Review With Meta‐Analysis of Randomized Controlled Trials

Pediatric Anesthesia, Volume 36, Issue 6, Page 628-640, June 2026.
ABSTRACT Background Emergence delirium commonly occurs in pediatric patients after general anesthesia, causing distress and potential harm. Remimazolam, an ultra‐short‐acting benzodiazepine, has recently been introduced in pediatric anesthesia, but its preventive role against emergence delirium remains unclear.
Ji‐Na Kim, Hyo‐Seok Na, Hyun‐Jung Shin   +2 more
wiley   +1 more source

Effect of remimazolam on postoperative delirium and cognitive function in adults undergoing general anesthesia or procedural sedation: a meta-analysis of randomized controlled trials

Korean Journal of Anesthesiology
Background Remimazolam is a novel short-acting benzodiazepine. This study compared the effects of remimazolam and propofol on cognitive function in adult patients after surgery or other procedures.
Ji-In Park, Hyo-Seok Na, Ji-Na Kim, J. Ryu, Howon Jang, Hyun-Jung Shin   +5 more
semanticscholar   +1 more source

Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial

Anaesthesia
Remimazolam, a short‐acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management of patients with multiple comorbidities remains unclear.
J. Fechner, K. El-Boghdadly, D. R. Spahn, J. Motsch, M. M. R. F. Struys, O. Duranteau, M. Ganter, T. Richter, M. Hollmann, R. Rossaint, S. Bercker, S. Rex, B. Drexler, F. Schippers, A. Morley, H. Ihmsen, E. Kochs   +16 more
semanticscholar   +1 more source

Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis

DEN Open
Objectives To compare the efficacy and safety of sedation with midazolam and remimazolam for colorectal endoscopy. Methods This single‐center, two‐arm, post‐hoc analysis of the REM‐IICTJP01 study investigated the efficacy and safety of remimazolam for ...
Kanako Ogura, Ryoji Ichijima, Hisatomo Ikehara, Tomomi Sugita, Daisuke Yamaguchi, Yasuhiko Nagata, Mitsuru Esaki, Yosuke Minoda, Hiroyuki Ono, Kinichi Hotta, Shinsuke Kiriyama, Tetsuya Sumiyoshi, Yuichi Kanmura   +12 more
doaj   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, Volume 13, Issue 23, 23 April 2026.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Remimazolam anaphylaxis in a patient not allergic to brotizolam: a case report and literature review

BMC Anesthesiology
Background Remimazolam is a recently developed, ultrashort-acting benzodiazepine that is used as a general anesthetic. Some cases of remimazolam anaphylaxis have been reported, but its characteristics are not fully understood.
Toshihiro Nakai, Eisuke Kako, Haruko Ota, MinHye So, Kazuya Sobue   +4 more
doaj   +1 more source

Investigation of the actual implementation of “post‐sedation discharge criteria” and “time‐out” immediately before procedure in endoscopy: A nationwide survey study in Japan

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Post‐sedation discharge criteria for outpatient endoscopy and time‐out procedures immediately before endoscopic examinations are important for ensuring patient safety. This study used a web‐based questionnaire to survey the implementation status and current situation of these practices in Japan in 2024.
Atsushi Imagawa, Motohiko Kato, Junko Koyama, Mitsuhiro Fujishiro   +3 more
wiley   +1 more source