Results 51 to 60 of about 2,162 (171)

Remimazolam attenuated lipopolysaccharide-induced behavioral deficits and neuronal injury via activation of the Nrf2 pathway

Scientific Reports
Sepsis is a severe disorder that is always accompanied by brain injury and dysfunction. This study aimed to evaluate the effects of remimazolam, a new ultra-short-acting sedative, on LPS-induced neuronal injury, and the role of Nrf2 signaling pathway ...
Yi Wei, Sining Pan, Zhan Zhou, Ying Yang, Tianxiao Liu, Jing Chen, Yubo Xie   +6 more
doaj   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, Volume 13, Issue 23, 23 April 2026.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Investigation of the actual implementation of “post‐sedation discharge criteria” and “time‐out” immediately before procedure in endoscopy: A nationwide survey study in Japan

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Post‐sedation discharge criteria for outpatient endoscopy and time‐out procedures immediately before endoscopic examinations are important for ensuring patient safety. This study used a web‐based questionnaire to survey the implementation status and current situation of these practices in Japan in 2024.
Atsushi Imagawa, Motohiko Kato, Junko Koyama, Mitsuhiro Fujishiro   +3 more
wiley   +1 more source

When Endoscopic Sedation is Not an Option: Insights From a Multicenter on‐site Survey on Tolerance for Japanese Gastric Cancer Screening

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Esophagogastroduodenoscopy (EGD) is widely used for gastric cancer (GC) screening in Japan; however, sedation during EGD is not recommended. We aimed to assess the tolerability of unsedated EGD (USEGD) in the Japanese population. Methods Participants who underwent GC screening in Japanese urban areas between July 2021 and December ...
Kazuya Inoki, Toshiya Chiba, Kazuhiro Miura, Teppei Tagawa, Yutaka Aoyagi, Yoshiaki Takeuchi, Naoya Moriyama, Kensuke Kuraoka, Tadashi Ohara, Yuko Haruhara, Akira Mizuki, Jun Satio, Yoshimi Hagisawa, Naomi Ono, Noboru Takayama, Takeo Onishi, Akira Mishima, Norihiro Suzuki, Kazuo Kikuchi, Atsushi Katagiri, Fuyuhiko Yamamura, Sachiko Ohde, Eisuke Inoue, Takahisa Matsuda, Hitoshi Yoshida   +24 more
wiley   +1 more source

Two cases of circulatory collapse due to suspected remimazolam anaphylaxis

JA Clinical Reports, 2022
Background Remimazolam was approved in Japan in January 2020. We report two cases of circulatory collapse due to suspected remimazolam anaphylaxis during anesthetic induction. Case presentation Case 1: A 74-year-old male was scheduled for debridement and
Satoshi Uchida, Daiki Takekawa, Masato Kitayama, Kazuyoshi Hirota   +3 more
doaj   +1 more source

Adverse Events of Single Balloon Enteroscopy‐assisted Endoscopic Retrograde Cholangiopancreatography in the Elderly: A Propensity Score Matching Analysis

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background Sedation for conventional endoscopic retrograde cholangiopancreatography (ERCP) has been reported to be safe even for elderly patients. However, the safety of sedation for balloon enteroscopy‐assisted ERCP (BE‐ERCP) has not been well‐studied in the elderly.
Hiroki Nakagawa, Tsuyoshi Takeda, Takeshi Okamoto, Takafumi Mie, Takaaki Furukawa, Takashi Sasaki, Masato Ozaka, Takahisa Matsuda, Yoshinori Igarashi, Naoki Sasahira   +9 more
wiley   +1 more source

Efficacy and Safety of Remimazolam Compared to Midazolam for Sedation During Endoscopic Ultrasonography: A Single‐Center Retrospective Cohort Study

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Remimazolam is a novel ultra–short‐acting benzodiazepine that may offer advantages over conventional sedatives in endoscopic procedures. Evidence for its use in pancreatobiliary endoscopic ultrasonography (EUS) is limited. We compared the efficacy and safety of remimazolam and midazolam in outpatient pancreatobiliary EUS.
Haruka Toyonaga, Makoto Masaki, Hajime Yamazaki, Arata Oka, Yoshiki Matsuno, Hidetoshi Nakata, Shoji Takayama, Tatsuya Nakagawa, Takuya Takayama, Masahiro Orino, Hironao Matsumoto, Kimi Sumimoto, Masahiro Takeo, Norimasa Fukata, Takeshi Yamashina, Masaaki Shimatani, Makoto Naganuma   +16 more
wiley   +1 more source

Remimazolam: a comprehensive review

Anaesthesiology Intensive Therapy
Remimazolam is a novel, ultra-short-acting benzodiazepine that has emerged as a promising agent in modern anesthetic and intensive care practice. This review pre­sents a detailed analysis of its pharmacokinetic and pharmacodynamic properties, clinical efficacy, and safety profile across various patient populations and procedural contexts.
Aleksander Aszkiełowicz, Cezary Kapłan, Patrycja Kapica, Rozalia Marszałek   +3 more
openaire   +2 more sources

Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis

DEN Open
Objectives To compare the efficacy and safety of sedation with midazolam and remimazolam for colorectal endoscopy. Methods This single‐center, two‐arm, post‐hoc analysis of the REM‐IICTJP01 study investigated the efficacy and safety of remimazolam for ...
Kanako Ogura, Ryoji Ichijima, Hisatomo Ikehara, Tomomi Sugita, Daisuke Yamaguchi, Yasuhiko Nagata, Mitsuru Esaki, Yosuke Minoda, Hiroyuki Ono, Kinichi Hotta, Shinsuke Kiriyama, Tetsuya Sumiyoshi, Yuichi Kanmura   +12 more
doaj   +1 more source

Remimazolam anaphylaxis in a patient not allergic to brotizolam: a case report and literature review

BMC Anesthesiology
Background Remimazolam is a recently developed, ultrashort-acting benzodiazepine that is used as a general anesthetic. Some cases of remimazolam anaphylaxis have been reported, but its characteristics are not fully understood.
Toshihiro Nakai, Eisuke Kako, Haruko Ota, MinHye So, Kazuya Sobue   +4 more
doaj   +1 more source