Results 71 to 80 of about 4,685 (255)

Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent

Frontiers in Pharmacology, 2021
A program to identify novel intravenous sedatives with a short and predictable duration of action was initiated in the late 1990’s by Glaxo Wellcome. The program focussed on the identification of ester-based benzodiazepine derivatives that are rapidly ...
Gavin J. Kilpatrick
doaj   +1 more source

Comparison of the effects of remimazolam and dexmedetomidine on early postoperative cognitive function in elderly patients with gastric cancer [PDF]

, 2023
PurposeTo compare the effects of remimazolam and dexmedetomidine on early postoperative cognitive dysfunction (POCD) in aged gastric cancer patients.MethodsFrom June to December 2022, 104 elderly patients (aged 65–80 years) received laparoscopic radical ...
Jia Min, Yong Qing Liao, Zheng Xia Wu, Zhi Hu   +3 more
core   +1 more source

Remimazolam attenuated lipopolysaccharide-induced behavioral deficits and neuronal injury via activation of the Nrf2 pathway

Scientific Reports
Sepsis is a severe disorder that is always accompanied by brain injury and dysfunction. This study aimed to evaluate the effects of remimazolam, a new ultra-short-acting sedative, on LPS-induced neuronal injury, and the role of Nrf2 signaling pathway ...
Yi Wei, Sining Pan, Zhan Zhou, Ying Yang, Tianxiao Liu, Jing Chen, Yubo Xie   +6 more
doaj   +1 more source

Association Between American Society of Anesthesiologists Physical Status Classification System and Remimazolam Sedation Outcomes

Academic Emergency Medicine, Volume 33, Issue 4, April 2026.
ABSTRACT Background Remimazolam (RM) is an ultrashort‐acting benzodiazepine with pharmacodynamic properties ideal for procedural sedation in emergency departments (EDs). This study evaluated the safety of RM when used for procedural sedation of American Society of Anesthesiologists (ASA) I–III patients in the ED. Aims To compare the occurrence of no or
Caroline H. Brynning, Simone P. Busch, Anne L. Krarup, Dorte Melgaard   +3 more
wiley   +1 more source

Interventions to prevent postoperative neurocognitive complications: an umbrella review of meta‐analyses of randomised controlled trials

Anaesthesia, Volume 81, Issue 4, Page 532-540, April 2026.
Summary Introduction The certainty of the effectiveness of interventions to manage postoperative neurocognitive complications remains unclear. The objective of this umbrella review was to synthesise and evaluate the evidence for interventions aimed at reducing the incidence of peri‐operative neurocognitive complications.
Filippo D'Amico, Stefano Turi, Marco Manazza, Giuliana Lo Bianco, Giacomo Monti, Alberto Zangrillo, Giovanni Landoni, Luigi Beretta   +7 more
wiley   +1 more source

Effect of remimazolam versus sevoflurane on intraoperative hemodynamics in noncardiac surgery: a retrospective observational study using propensity score matching [PDF]

浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科Background　This study compared the effects of remimazolam and sevoflurane on intraoperative hemodynamics including intraoperative hypotension (IOH).
Katsuragawa, Takayuki, カツラガワ, タカユキ, 桂川, 孝行   +2 more
core   +1 more source

Remimazolam: a comprehensive review

Anaesthesiology Intensive Therapy
Remimazolam is a novel, ultra-short-acting benzodiazepine that has emerged as a promising agent in modern anesthetic and intensive care practice. This review pre­sents a detailed analysis of its pharmacokinetic and pharmacodynamic properties, clinical efficacy, and safety profile across various patient populations and procedural contexts.
Aleksander Aszkiełowicz, Cezary Kapłan, Patrycja Kapica, Rozalia Marszałek   +3 more
openaire   +2 more sources

Ciprofol May Represent a Useful Sedative Option for Gastrointestinal Endoscopy

Digestive Endoscopy, Volume 38, Issue 5, May 2026.
Takeshi Yamamura, Masanao Nakamura, Hiroki Kawashima   +2 more
wiley   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, Volume 3, Issue 1, March 2026.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol:a multicentre randomised controlled trial [PDF]

Remimazolam, a short-acting benzodiazepine, may be used for induction and maintenance of total intravenous anaesthesia, but its role in the management of patients with multiple comorbidities remains unclear.
, Bercker, S., Drexler, B., Duranteau, O., El-Boghdadly, K., Fechner, J., Ganter, M. T., Hollmann, M. W., Ihmsen, H., Kochs, E., Morley, A., Motsch, J., Rex, S., Richter, T., Rossaint, R., Schippers, F., Spahn, D. R., Struys, M. M. R. F.   +17 more
core   +1 more source