Results 121 to 130 of about 10,594 (253)

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]

, 2019
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra, Awad, Mohamed E., Eisa, Nada H., Elmansi, Ahmed M., Fulzele, Sadanand, Hamrick, Mark W., Herberg, Samuel, Hill, William D., Hussein, Khaled A., Isales, Carlos M., Kondrikov, Dmitry, McGee-Lawrence, Meghan E., Periyasamy-Thandavan, Sudharsan, Volkman, Brian F.   +13 more
core   +1 more source

Chronic remote ischemic conditioning for cardiovascular protection.

Conditioning medicine, 2019
New treatments are needed to prevent adverse left ventricular remodelling following acute myocardial infarction (AMI), in order to prevent heart failure and improve clinical outcomes following AMI. Remote ischemic conditioning (RIC) using transient limb ischemia and reperfusion has been reported to reduce myocardial infarct (MI) size in AMI patients ...
Chong, J, Bulluck, H, Fw Ho, A, Boisvert, WA, Hausenloy, DJ   +4 more
openaire   +2 more sources

Measurement of Active Thrombin Bound to Circulating D‐Dimers as a Sensitive Biomarker for Prothrombotic Conditions

Journal of Clinical Laboratory Analysis, EarlyView.
Scheme of preparation of D‐dimers and evaluation of D‐dimer‐bound thrombin activity. Thrombin bound to fibrin participates in ongoing fibrinogen transformation and its inhibition is impeded. Our detection system may aid in identifying patients at risk of recurrent thrombotic events or complications, regardless of the origin of the acute health problem.
Jana Stikarova, Leona Chrastinova, Kristyna Svobodova, Marek Havlicek, Jan Louzil, Eliska Ceznerova, Alzbeta Hlavackova, Ondrej Pastva, Pavla Pecherkova, Ingrid Hrachovinova, Ondrej Kucerka, Roman Kotlin, Petr Soukup, Peter Salaj, Martin Maly, Jiri Suttnar   +15 more
wiley   +1 more source

Larger infarct size but equal protection by ischemic conditioning in septum and anterior free wall of pigs with LAD occlusion

Physiological Reports, 2019
The ischemic area at risk (AAR) is one major determinant of infarct size (IS). In patients, the largest AAR is seen with a proximal occlusion of the left anterior descending (LAD) coronary artery, which serves parts of the septum and of the anterior free
Andreas Skyschally, Helene Hagelschuer, Petra Kleinbongard, Gerd Heusch   +3 more
doaj   +1 more source

Reperfusion, conditioning and the ongoing search for the holy grail [PDF]

, 2017
schaemic conditioning is the phenomenon of protection against reperfusion injury via the application of brief, repeated episodes of non-lethal ischaemia.
Bell, RM, Yellon, RL
core  

Renoprotection by remote ischemic conditioning during elective coronary revascularization: A systematic review and meta-analysis of randomized controlled trials [PDF]

, 2016
BACKGROUND: Remote ischemic conditioning (RIC) has been recognized an emerging non-invasive approach for preventing acute kidney injury (AKI) in patients undergoing either elective coronary artery bypass graft (CABG) surgery or percutaneous coronary ...
Hausenloy, DJ, Jeon, Y, Li, L, Meybohm, P, Young, PJ, Zarbock, A, Zhou, C   +6 more
core   +1 more source

Enriched Environment Enhances Motor Function in Mice With Cerebral Infarction by Promoting mTOR‐Dependent Autophagy in the Contralateral Dentate Nucleus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Although environmental enrichment (EE) promotes post‐stroke motor recovery, the mechanisms underlying its regulation of cerebellar dentate nucleus (DN) plasticity remain unclear; this study therefore investigated how EE coordinates autophagy, mitochondrial homeostasis, and synaptic remodeling in the contralateral DN to facilitate functional ...
Chuan‐Jie Wang, Ke‐Wei Yu, Jun‐Fa Wu, Feng Tao   +3 more
wiley   +1 more source

One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia [PDF]

, 2017
Application of repeated short duration bouts of ischemia to the limbs, termed remote ischemic preconditioning (RIPC), is a novel technique that may have protective effects on vascular function during hypoxic exposures. In separate parallel-design studies,
Ainslie, Antezana, Anthony R. Bain, Arroyo-Martínez, Atkinson, Atkinson, Atkinson, Bailey, Bailey, Bakker, Berger, Berger, Candilio, Chen, Costa, Daniela Flück, Dave, Dorrington, Eisen, Foster, Foster, Frøbert, Gattullo, Gho, Hackett, Hausenloy, James D. Anholm, Jones, Jones, Joshua C. Tremblay, Kimura, Kinoshita, Koch, Koch, Lambert, Lewis, Lim, Liu, Maggiorini, Man, Mathew G. Rieger, Meng, Meybohm, Mike Stembridge, Murry, Münzel, Nurse, Philip N. Ainslie, Prabhakar, Prajan Subedi, Pyke, Pérez-Pinzón, Ren, Rudski, Ryan L. Hoiland, Sartori, Schoene, Severinghaus, Severinghaus, Stembridge, Stenmark, Swenson, Tapuria, Thielmann, Thijssen, Tremblay, Tymko, Tymko, Tymko, Vejlstrup, Wever, Willie, Willie, Woodman, Yan   +74 more
core   +1 more source

Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4‐Year Follow‐Up Cohort Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA) are comorbid conditions that synergistically increase cardiovascular risk through systemic inflammation and insulin resistance. While continuous positive airway pressure (CPAP) is the standard treatment for OSA, its efficacy in improving hepatic ...
Hsiao‐Chin Shen, Yen‐Hsun Huang, Tzu‐Hao Li, Chih‐Hsun Wu, Yu‐Wei Lee, Hsiao‐Yun Yeh, Hung‐Cheng Tsai, Chien‐Wei Su, Kun‐Ta Chou, Ying‐Ying Yang, Ming‐Chih Hou   +10 more
wiley   +1 more source

Remote tissue conditioning is neuroprotective against MPTP insult in mice

IBRO Reports, 2018
Current treatments for Parkinson’s disease (PD) are primarily symptomatic, leaving a need for treatments that mitigate disease progression. One emerging neuroprotective strategy is remote tissue conditioning, in which mild stress in a peripheral tissue ...
Boaz Kim, John Mitrofanis, Jonathan Stone, Daniel M. Johnstone   +3 more
doaj   +1 more source