Results 141 to 150 of about 3,792 (227)
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun +6 more
wiley +1 more source
ABSTRACT Background and Aims Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent whose clinical utility is significantly constrained by severe side effects, most notably DOX‐induced cardiotoxicity (DIC). Pathophysiological mechanisms of DIC include oxidative stress, mitochondrial dysfunction, programmed cell death, and inflammation ...
Ali Mirzaei +8 more
wiley +1 more source
Neuroprotective Effect of Remote Ischemic Conditioning on Patients Undergoing Intravenous Thrombolysis: A Randomized Controlled Trial. [PDF]
Qi S +11 more
europepmc +1 more source
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie +3 more
wiley +1 more source
Quantitative proteomic analysis of plasma after remote ischemic conditioning in acute ischemic stroke. [PDF]
Cui Y, Liu F, Cai JR, Chen HS.
europepmc +1 more source
QRS notch/slur resolution during LV‐only fusion pacing, combined with an LV‐only pacing percentage ≥ 50% at 1 month, was independently associated with early left ventricular reverse remodeling and may help guide post‐implant CRT optimization. ABSTRACT Background Cardiac resynchronization therapy (CRT) improves outcomes in patients with heart failure ...
Junji Morita +7 more
wiley +1 more source
Remote Ischemic Conditioning as an Adjunct to Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis. [PDF]
Khormi MA +11 more
europepmc +1 more source
SIRT Family: Biological Functions and Therapeutic Targets
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang +9 more
wiley +1 more source
Remote ischemic conditioning for cerebral ischemia in patients with Takayasu arteritis (TARIC-1): Study protocol. [PDF]
Huang S +8 more
europepmc +1 more source

