Results 141 to 150 of about 3,792 (227)

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

open access: yesAdvanced Science, Volume 13, Issue 43, 3 August 2026.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun   +6 more
wiley   +1 more source

The Therapeutic Potential of Stem Cell Therapy for Doxorubicin‐Induced Cardiotoxicity: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent whose clinical utility is significantly constrained by severe side effects, most notably DOX‐induced cardiotoxicity (DIC). Pathophysiological mechanisms of DIC include oxidative stress, mitochondrial dysfunction, programmed cell death, and inflammation ...
Ali Mirzaei   +8 more
wiley   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie   +3 more
wiley   +1 more source

Association of QRS Notch Resolution During LV‐Only Fusion Pacing With Early Left Ventricular Reverse Remodeling After Cardiac Resynchronization Therapy

open access: yesJournal of Arrhythmia, Volume 42, Issue 4, August 2026.
QRS notch/slur resolution during LV‐only fusion pacing, combined with an LV‐only pacing percentage ≥ 50% at 1 month, was independently associated with early left ventricular reverse remodeling and may help guide post‐implant CRT optimization. ABSTRACT Background Cardiac resynchronization therapy (CRT) improves outcomes in patients with heart failure ...
Junji Morita   +7 more
wiley   +1 more source

Remote Ischemic Conditioning as an Adjunct to Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis. [PDF]

open access: yesCureus
Khormi MA   +11 more
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang   +9 more
wiley   +1 more source

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