Results 211 to 220 of about 21,165 (234)

Human oligodendrocytes in remyelination research

Glia, 2014
Studies on myelination and oligodendrocyte development are inevitably linked with demyelinating conditions such as multiple sclerosis (MS), leukodystrophies or spinal cord injury (SCI). Chronic loss of myelin, subsequently leading to neurodegeneration, is the ultimate cause of severe and permanent disability. Thus, fast restoration
Marcin, Czepiel, Erik, Boddeke, Sjef, Copray   +2 more
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Signaling for Remyelination

Science Signaling, 2013
Inhibiting SIRT1 may improve demyelinating neuropathies by inducing the expansion of myelin-producing oligodendrocytes.
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Central remyelination restores secure conduction

Nature, 1979
ONE of the outstanding characteristics of multiple sclerosis and other clinical and experimental diseases associated with demyelination, is the tendency to remit. Although there is good evidence that an important cause of functional loss in such conditions is conduction block produced by the selective destruction of the myelin sheath1, the mechanisms ...
K J, Smith, W F, Blakemore, W I, McDonald   +2 more
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Remyelination: Cellular and gene therapy

Seminars in Pediatric Neurology, 1998
Dysfunctional myelination or oligodendroglial abnormalities play a prominent role in a vast array of pediatric neurological diseases of genetic, inflammatory, immunological, traumatic, ischemic, developmental, metabolic, and infectious causes. Recent advances in glial cell biology have suggested that effective remyelination strategies may, indeed, be ...
L L, Billinghurst, R M, Taylor, E Y, Snyder   +2 more
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Demyelination and Remyelination

Advances in Neurobiology
Myelinating oligodendrocytes and oligodendrocyte precursor cells (OPCs) make up half the cells in the central nervous system and are affected by and contribute to all neurological diseases. The pathology of myelinating oligodendrocytes is fundamentally characterized by myelin disruption and loss, termed demyelination, whereas that of OPCs is ...
Niu, Jianqin, Verkhratsky, Alexei, Butt, Arthur, Yi, Chenju   +3 more
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Remyelination: a brief history

The Lancet Neurology, 2020
Catherine, Lubetzki, Bernard, Zalc
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Mechanisms and Medicines for Remyelination

Annual Review of Medicine, 2017
Demyelination of central nervous system axons, associated with traumatic injury and demyelinating diseases such as multiple sclerosis, causes impaired neural transmission and ultimately axon degeneration. Consequently, extensive research has focused on signaling systems that promote myelinating activity of oligodendrocytes or promote production of new
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Transnodal remyelination

The Journal of Pathology, 1970
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Remyelination

2002
James W. Fawcett, Anne E. Rosser, Stephen B. Dunnett   +2 more
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Remyelination in Human CNS Lesions

1980
Publisher Summary Medical prognosis with regard to human CNS lesions has been poor— the general view being that most of these lesions show no tendency to functional recovery. Studies on Wallerian and retrograde degeneration, in particular, gave the impression that repair in the CNS is a rare phenomenon as the axon as well as the myelin sheath ...
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