Results 201 to 210 of about 22,271 (244)
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Macrophages and CNS remyelination
Journal of Neurochemistry, 2014AbstractMicroglia are the resident macrophages of the central nervous system that survey the microenvironment for signals of injury or infection. The response to such signals induces an inflammatory response involving macrophages derived from both resident microglia and recruited circulating monocytes.
Veronique E, Miron, Robin J M, Franklin
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Pattern of Remyelination in the CNS
Nature, 1973FOR more than a decade it has been known1–3 that glial cells are capable of forming new myelin sheaths around demye-linated axons in the central nervous system (CNS) but it is not known whether the new myelin is formed into segments bounded by true nodes and, if it is, whether the internodal length is appropriate to the axon diameter or inappropriately
R F, Gledhill +2 more
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Multiple Sclerosis Journal, 1997
Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
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Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
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Remyelination in multiple sclerosis
Multiple Sclerosis Journal, 1997Stimulation of remyelination in multiple sclerosis lesions may be one possible therapeutic approach. However, since the pathology and pathogenesis of multiple sclerosis may be heterogeneous, it is important to analyze in what patients and at what stages of the disease such a therapy can be reasonable and feasible.
H, Lassmann +3 more
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Pattern of remyelination in the CNS
Nature, 1974IT has been suggested that reduction of internodal length may be a feature of remyelinated central nerve fibres as it is of peripheral nerve fibres1. As the technique for measuring internodal length of nerve fibres in the central nervous system (CNS) is tedious and requires a high degree of skill and patience from the investigator2, it is unlikely that
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Mechanisms and Medicines for Remyelination
Annual Review of Medicine, 2017Demyelination of central nervous system axons, associated with traumatic injury and demyelinating diseases such as multiple sclerosis, causes impaired neural transmission and ultimately axon degeneration. Consequently, extensive research has focused on signaling systems that promote myelinating activity of oligodendrocytes or promote production of new
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The role of NCAM in remyelination
Neurological Sciences, 2002The neural cell adhesion molecule (NCAM) is expressed by myelinating precursor cells in neonatal mouse spinal cord and by remyelinating cells after chemically induced demyelination in adult mouse. It shows tempting suggestions about its possible involvement in the reparative mechanisms and the remyelination processes that take place in multiple ...
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THE RESTORATION OF CONDUCTION BY CENTRAL REMYELINATION
Brain, 1981Conduction has been examined serially through the experimental demyelinating lesion produced by the direct micro-injection of lysophatidyl choline into the cat spinal cord. Conduction was blocked during the phase of demyelination. Remyelination commenced during the latter part of the second week, and conduction through the lesion was restored in some ...
K J, Smith +2 more
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Remyelination in the CNS of the hypothyroid rat
NeuroReport, 1996A number of studies have provided good evidence to indicate a role for thyroid hormone in myelination. Since myelination and remyelination have many shared objectives, and may therefore involve similar mechanisms, we examined whether thyroid hormone may also have a role in remyelination by both Schwann cells and oligodendrocytes of spinal cord axons ...
R J, Franklin, J M, Gilson
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Remyelination in the chicken sciatic nerve
Neurochemistry International, 1982Remyelination in the chicken sciatic nerve occurring after the injection of diphtheria toxin was studied. The rates of fast axonal transport and conduction velocities were measured sixty days after the injection of the toxin. Fast axonal transport rates were found to have returned to normal in the remyelinated nerves, but conduction velocity was ...
M A, Hanwell, N A, Cooper, A D, Kidman
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