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Remyelination in multiple sclerosis
Multiple Sclerosis Journal, 1997Stimulation of remyelination in multiple sclerosis lesions may be one possible therapeutic approach. However, since the pathology and pathogenesis of multiple sclerosis may be heterogeneous, it is important to analyze in what patients and at what stages of the disease such a therapy can be reasonable and feasible.
H, Lassmann +3 more
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Multiple Sclerosis Journal, 1997
Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
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Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
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Remyelination in multiple sclerosis
2009Remyelination in multiple sclerosis is in most cases insufficient, leading to irreversible disability. Different and nonexclusive factors account for this repair deficit. Local inhibitors of the differentiation of oligodendrocyte progenitor cells (OPCs) might play a role, as well as axonal factors impairing the wrapping process. Alternatively, a defect
Gabrièle, Piaton +3 more
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Remyelination during optic nerve compression
Journal of the Neurological Sciences, 1980The structural changes produced in cat optic nerve by incremental chronic compression have been investigated by light and electron microscopy. Within the first week extensive demyelination occurred; some fibres underwent Wallerian degeneration and there was marked proliferation of astrocytic processes.
R E, Clifford-Jones +2 more
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Human oligodendrocytes in remyelination research
Glia, 2014Studies on myelination and oligodendrocyte development are inevitably linked with demyelinating conditions such as multiple sclerosis (MS), leukodystrophies or spinal cord injury (SCI). Chronic loss of myelin, subsequently leading to neurodegeneration, is the ultimate cause of severe and permanent disability. Thus, fast restoration
Marcin, Czepiel +2 more
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Science Signaling, 2013
Inhibiting SIRT1 may improve demyelinating neuropathies by inducing the expansion of myelin-producing oligodendrocytes.
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Inhibiting SIRT1 may improve demyelinating neuropathies by inducing the expansion of myelin-producing oligodendrocytes.
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Central remyelination restores secure conduction
Nature, 1979ONE of the outstanding characteristics of multiple sclerosis and other clinical and experimental diseases associated with demyelination, is the tendency to remit. Although there is good evidence that an important cause of functional loss in such conditions is conduction block produced by the selective destruction of the myelin sheath1, the mechanisms ...
K J, Smith +2 more
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Remyelination: Cellular and gene therapy
Seminars in Pediatric Neurology, 1998Dysfunctional myelination or oligodendroglial abnormalities play a prominent role in a vast array of pediatric neurological diseases of genetic, inflammatory, immunological, traumatic, ischemic, developmental, metabolic, and infectious causes. Recent advances in glial cell biology have suggested that effective remyelination strategies may, indeed, be ...
L L, Billinghurst +2 more
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Demyelination and Remyelination
Advances in NeurobiologyMyelinating oligodendrocytes and oligodendrocyte precursor cells (OPCs) make up half the cells in the central nervous system and are affected by and contribute to all neurological diseases. The pathology of myelinating oligodendrocytes is fundamentally characterized by myelin disruption and loss, termed demyelination, whereas that of OPCs is ...
Niu, Jianqin +3 more
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