Results 191 to 200 of about 25,880 (231)

Mechanisms and Medicines for Remyelination

Annual Review of Medicine, 2017
Demyelination of central nervous system axons, associated with traumatic injury and demyelinating diseases such as multiple sclerosis, causes impaired neural transmission and ultimately axon degeneration. Consequently, extensive research has focused on signaling systems that promote myelinating activity of oligodendrocytes or promote production of new
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The role of NCAM in remyelination

Neurological Sciences, 2002
The neural cell adhesion molecule (NCAM) is expressed by myelinating precursor cells in neonatal mouse spinal cord and by remyelinating cells after chemically induced demyelination in adult mouse. It shows tempting suggestions about its possible involvement in the reparative mechanisms and the remyelination processes that take place in multiple ...
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THE RESTORATION OF CONDUCTION BY CENTRAL REMYELINATION

Brain, 1981
Conduction has been examined serially through the experimental demyelinating lesion produced by the direct micro-injection of lysophatidyl choline into the cat spinal cord. Conduction was blocked during the phase of demyelination. Remyelination commenced during the latter part of the second week, and conduction through the lesion was restored in some ...
K J, Smith, W F, Blakemore, W I, McDonald   +2 more
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Endogenous or exogenous oligodendrocytes for remyelination

Journal of the Neurological Sciences, 2008
The relative merits of endogenous and exogenous oligodendrocyte progenitor cells (OPCs) for remyelination are compared in terms of their ability to repopulate OPC-depleted tissue and generate remyelinating oligodendrocytes. Exogenous neonatal OPCs can repopulate OPC-depleted tissue 5-10 times faster than endogenous cells and as a result are capable of ...
W F, Blakemore, K-A, Irvine
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Remyelination — An effective means of neuroprotection

Hormones and Behavior, 2010
Remyelination following central nervous system (CNS) demyelination restores rapid saltatory conduction of action potentials and contributes to the maintenance of axonal integrity. This robust regenerative phenomenon stands in contrast to the limited repair capacity that is characteristic of CNS neuronal injury.
Charlotte C, Bruce, Chao, Zhao, Robin J M, Franklin   +2 more
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Signaling for Remyelination

Science Signaling, 2013
Inhibiting SIRT1 may improve demyelinating neuropathies by inducing the expansion of myelin-producing oligodendrocytes.
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Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

Annals of Neurology, 1993
AbstractThe relationship between plaque pathology and disease duration was examined in 15 patients with multiple sclerosis who died early in the course of their illness. Myelin‐stained sections revealed that most plaques examined in patients who died during the first month of their illness showed evidence of ongoing myelin destruction accompanied by a ...
J. W. Prineas, R. O. Barnard, E. E. Kwon, L. R. Sharer, E.‐S. Cho   +4 more
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Remyelination in the CNS of the hypothyroid rat

NeuroReport, 1996
A number of studies have provided good evidence to indicate a role for thyroid hormone in myelination. Since myelination and remyelination have many shared objectives, and may therefore involve similar mechanisms, we examined whether thyroid hormone may also have a role in remyelination by both Schwann cells and oligodendrocytes of spinal cord axons ...
R J, Franklin, J M, Gilson
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Remyelination in the chicken sciatic nerve

Neurochemistry International, 1982
Remyelination in the chicken sciatic nerve occurring after the injection of diphtheria toxin was studied. The rates of fast axonal transport and conduction velocities were measured sixty days after the injection of the toxin. Fast axonal transport rates were found to have returned to normal in the remyelinated nerves, but conduction velocity was ...
M A, Hanwell, N A, Cooper, A D, Kidman
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Review of the Morphological Aspects of Remyelination

Developmental Neuroscience, 1989
The advent of proper preparative and experimental techniques has allowed us to investigate the central nervous system myelin both in the normal animal and during remyelination. Remyelination often follows the pattern of myelination during development but, in addition, shows certain variations such as participation of Schwann cells, and is apparently ...
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