Results 181 to 190 of about 25,880 (231)
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Multiple Sclerosis Journal, 1997
Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
Frederik Barkhof
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Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
Frederik Barkhof
exaly +3 more sources
REMYELINATION IN MULTIPLE SCLEROSIS
Journal of Neuropathology and Experimental Neurology, 1978AbstractChronic plaques in central nervous system tissue fixed by in situe perfusion for electron microscopy were examined for evidence of remyelination in 2 patients with multiple sclerosis (MS). Fibers with abnormal central myelin sheaths of several types were found at the margins of most of the plaques studied. The most common of these were: (1) the
J W, Prineas, F, Connell
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NeuroReport, 2002
Remyelination of demyelinated axons in the CNS is a regenerative process that, like many others, becomes less efficient with age. This article reviews a series of studies in which toxin models of demyelination have been used to characterize this phenomenon.
Robin J M, Franklin +2 more
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Remyelination of demyelinated axons in the CNS is a regenerative process that, like many others, becomes less efficient with age. This article reviews a series of studies in which toxin models of demyelination have been used to characterize this phenomenon.
Robin J M, Franklin +2 more
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Remyelination in multiple sclerosis
Progress in Brain Research, 2009Remyelination in multiple sclerosis is in most cases insufficient, leading to irreversible disability. Different and nonexclusive factors account for this repair deficit. Local inhibitors of the differentiation of oligodendrocyte progenitor cells (OPCs) might play a role, as well as axonal factors impairing the wrapping process. Alternatively, a defect
Catherine Lubetzki +2 more
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Macrophages and CNS remyelination
Journal of Neurochemistry, 2014AbstractMicroglia are the resident macrophages of the central nervous system that survey the microenvironment for signals of injury or infection. The response to such signals induces an inflammatory response involving macrophages derived from both resident microglia and recruited circulating monocytes.
Veronique E, Miron, Robin J M, Franklin
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Pattern of Remyelination in the CNS
Nature, 1973FOR more than a decade it has been known1–3 that glial cells are capable of forming new myelin sheaths around demye-linated axons in the central nervous system (CNS) but it is not known whether the new myelin is formed into segments bounded by true nodes and, if it is, whether the internodal length is appropriate to the axon diameter or inappropriately
R F, Gledhill +2 more
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Fibronectin aggregation in multiple sclerosis lesions impairs remyelination
Brain, 2013 Remyelination following central nervous system demyelination is essential to prevent axon degeneration. However, remyelination ultimately fails in demyelinating diseases such as multiple sclerosis. This failure of remyelination is likely mediated by many
Robin Franklin, Wia Baron, Chao Zhao
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Remyelination in multiple sclerosis
Multiple Sclerosis Journal, 1997Stimulation of remyelination in multiple sclerosis lesions may be one possible therapeutic approach. However, since the pathology and pathogenesis of multiple sclerosis may be heterogeneous, it is important to analyze in what patients and at what stages of the disease such a therapy can be reasonable and feasible.
H, Lassmann +3 more
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Pattern of remyelination in the CNS
Nature, 1974IT has been suggested that reduction of internodal length may be a feature of remyelinated central nerve fibres as it is of peripheral nerve fibres1. As the technique for measuring internodal length of nerve fibres in the central nervous system (CNS) is tedious and requires a high degree of skill and patience from the investigator2, it is unlikely that
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Evoked potentials as a biomarker of remyelination [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Remyelination is a critical therapeutic target in MS that will restore function and protect demyelinated axons. Clinical trials of putative remyelination-promoting drugs depend on valid, robust, and noninvasive outcome measures.
Gillian J Mclellan +2 more
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