Results 181 to 190 of about 34,938 (236)

Glial Cells as Key Mediators in the Pathophysiology of Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Bogus K, Marchesi N, Campagnoli LIM, Pascale A, Pałasz A.   +4 more
europepmc   +1 more source

Remyelination of chronic demyelinated lesions with directly induced neural stem cells. [PDF]

Brain
Peruzzotti-Jametti L, Vicario N, Volpe G, Rizzi S, Kwok C, Lombardi I, Bergholt MS, Barea-Moya L, D'Angelo A, Nicaise AM, D'Amico G, Krzak G, Willis CM, Gil-Perotin S, Hruba O, Braga A, Stevens MM, Garcia-Verdugo JM, Saeb-Parsy K, Zhao C, Franklin RJM, Edenhofer F, Pluchino S.   +22 more
europepmc   +1 more source

Pillars of remyelination [PDF]

Nature Reviews Drug Discovery, 2014
Megan Cully
exaly   +2 more sources

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REMYELINATION IN MULTIPLE SCLEROSIS

Journal of Neuropathology and Experimental Neurology, 1978
AbstractChronic plaques in central nervous system tissue fixed by in situe perfusion for electron microscopy were examined for evidence of remyelination in 2 patients with multiple sclerosis (MS). Fibers with abnormal central myelin sheaths of several types were found at the margins of most of the plaques studied. The most common of these were: (1) the
J W, Prineas, F, Connell
openaire   +2 more sources

Ageing and CNS remyelination

NeuroReport, 2002
Remyelination of demyelinated axons in the CNS is a regenerative process that, like many others, becomes less efficient with age. This article reviews a series of studies in which toxin models of demyelination have been used to characterize this phenomenon.
Robin J M, Franklin, Chao, Zhao, Fraser J, Sim   +2 more
openaire   +2 more sources

Macrophages and CNS remyelination

Journal of Neurochemistry, 2014
AbstractMicroglia are the resident macrophages of the central nervous system that survey the microenvironment for signals of injury or infection. The response to such signals induces an inflammatory response involving macrophages derived from both resident microglia and recruited circulating monocytes.
Veronique E, Miron, Robin J M, Franklin
openaire   +2 more sources

TREM2 activation promotes remyelination

Nature Reviews Neurology, 2020
Cignarella, F. et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. https://doi.org/10.1007/s00401-020-02193-z (2020) Article PubMed Google Scholar Ulland, T. K. & Colonna, M. TREM2 — a key player in microglial biology and Alzheimer disease. Nat. Rev. Neurol. 14, 667–
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