Results 51 to 60 of about 591,781 (298)

Multimodal Deep Learning for Prognosis Prediction in Renal Cancer

Frontiers in Oncology, 2021
BackgroundClear-cell renal cell carcinoma (ccRCC) is common and associated with substantial mortality. TNM stage and histopathological grading have been the sole determinants of a patient’s prognosis for decades and there are few prognostic biomarkers ...
Stefan Schulz, Ann-Christin Woerl, Ann-Christin Woerl, Florian Jungmann, Christina Glasner, Philipp Stenzel, Stephanie Strobl, Aurélie Fernandez, Daniel-Christoph Wagner, Axel Haferkamp, Peter Mildenberger, Wilfried Roth, Sebastian Foersch   +12 more
doaj   +1 more source

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization [PDF]

, 1994
We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entire chromosomes with underrepresentation of chromosome 1 ...
Speicher, Michael R., Cremer, Thomas, Kovacs, Gyula, Störkel, S., Ried, Thomas, Schoell, B., Manoir, Stanislas du, Schröck, Evelin   +7 more
core  

An Independent Validation of 2010 Tumor-Node-Metastasis Classification for Renal Cell Carcinoma: A Multi-center Study by the Urooncology Association of Turkey Renal Cancer-Study Group [PDF]

, 2017
Objective: The American Joint Committee on Cancer tumor-node-metastasis (TNM) classification has been updated by the 7th edition in 2010. The objective of the study was to evaluate cancer-specific survival (CSS) in patients with renal cell carcinoma (RCC)
Ozen, Haluk, Dirim, Ayhan, Urooncology Association of Turkey Renal Cancer-Study Group, Cavit Can, Yildirim, Asif, Asıf Yıldırım, Can, Cavit, Haluk Özen, Çağatay Göğüs, Ozkan, Tayyar Alp, Akdogan, Bulent, Gogus, Cagatay, Tayyar Alp Özkan, Saadettin Eskiçorapçı, Turkeri, Levent, Eskicorapci, Sadettin, Renal, Urooncology Assoc Turkey, Özgür Yaycıoğlu, Tukeri, Levent, Levent Türkeri, Ayhan Dirim, Bülent Akdoğan, Yaycioglu, Ozgur, Eskicorapci, Saadettin, Urooncology Association of Turkey Renal Cancer Study Group   +24 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hereditary leiomyomatosis and renal cell cancer (HLRCC): A case report

Urology Case Reports, 2020
Hereditary leiomyomatosis and renal cell cancer is a rare, inherited disease caused by mutations in the fumarate hydratase gene. It is characterized by cutaneous leiomyomas, uterine leiomyomas, and/or renal cell cancer.
Tomoko Yonamine, Tadashi Kaname, Yasutsugu Chinen, Kouichi Tamashiro, Noritake Kosuge, Seiichi Saito   +5 more
doaj   +1 more source

Clinical application of indocyanine green fluorescence imaging navigation for pediatric renal cancer

Frontiers in Pediatrics, 2023
BackgroundIndocyanine Green (ICG) fluorescence imaging has been widely used in the surgical treatment of adult renal cancers, but its application in pediatric renal cancers has rarely been reported.
Jun Feng, Wei Yang, Hong Qin, Jiatong Xu, Shan Liu, Jianyu Han, Ning Li, Lejian He, Huanmin Wang   +8 more
doaj   +1 more source

Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells [PDF]

, 2009
Background Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors have now opened novel treatment options.
Natsheh, Iyad Y. M., Eva Juengel, Mickuckyte, Ausra, Hudak, Lukasz, Jones, Jon, Roman A Blaheta, Lukasz Hudak, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Johanna Engler, Iyad Natsheh, Ausra Mickuckyte, Jonas, Dietger, Jon Jones, Engler, Johanna   +15 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Renal capsule metastasis from renal pelvic cancer: a case report

BMC Urology, 2018
Background Metastatic renal cancers are relatively common. Most are metastases to the renal parenchyma via a hematogenous route and are derived from lung, breast, and gastrointestinal cancer, malignant melanoma, and hematologic malignant cancer. However,
Yasuyuki Kobayashi, Hiroki Arai, Masahito Honda, Takashi Matsumoto, Kyotaro Yoshida   +4 more
doaj   +1 more source