Results 91 to 100 of about 72,813 (290)
Multiple Drug Transporters Are Involved in Renal Secretion of Entecavir [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT Entecavir (ETV) is a first-line antiviral agent for the treatment of chronic hepatitis B virus infection. Renal excretion is the major elimination path of ETV, in which tubular secretion plays the key role. However, the secretion mechanism has not been clarified.
Xi, Yang +7 more
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Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Advanced Healthcare Materials, EarlyView.Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2018 Number of drugs with different mechanisms of actions is undergoing clinical trials for non-alcoholic steatohepatitis (NASH). Given the complexity of the disease with respect to pathophysiology in the liver and associated changes in the renal function, it
Ranjeet Prasad Dash +2 more
doaj +1 more source
Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin
Asian Journal of Pharmaceutical Sciences, 2020 This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of ...
Yanna Zhu +9 more
doaj +1 more source
Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
, 2018 Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
core +1 more source
Topics on transporter-mediated renal excretion and drug–drug interaction.
Folia Pharmacologica Japonica, 2010 薬物の尿中排泄には腎での糸球体濾過と尿細管分泌が関わっている．中でも尿細管分泌は腎尿細管上皮細胞の刷子縁膜および側底膜に存在しているトランスポーターが協働する方向性を持った物質輸送過程であり，近年，トランスポーターの実態が分子レベルで次々と明らかにされ，尿細管分泌過程における特定のトランスポーターを介した薬物間相互作用についても報告がなされている．これまで，医薬品開発における腎排泄に関しての検討では，事象をマクロ的に捉えることが主であり，その多くが腎機能低下（加齢，疾患，薬剤）による血中薬物濃度推移等の薬物動態変化を把握し，情報提供するというものであった．これらの情報は臨床使用上非常に重要ではあるが，腎排泄に関わるトランスポーターの実態が明らかとなった今日，特にin ...
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad +2 more
wiley +1 more source
Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium [PDF]
, 2015 The low renal excretion of betaine indicates that the kidney efficiently reabsorbs the betaine filtered by the glomeruli but the mechanisms involved in such a process have been scarcely investigated.
Calonge Castrillo, María Luisa +2 more
core +1 more source
Advanced Materials, EarlyView.A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee +8 more
wiley +1 more source
Hypothyroidism and nephrotic syndrome: why, when and how to treat [PDF]
, 2017 Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS).
Barbano, Biagio +7 more
core +1 more source