Results 31 to 40 of about 72,813 (290)

Uremic Toxins in Organ Crosstalk

Frontiers in Medicine, 2021
Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj   +1 more source

An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]

, 2012
Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Danish Ahmed, Manju Sharma, Pankaj S Yadav, Vikas Kumar   +3 more
core   +2 more sources

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
Abosaif, Andres-Hernando, Andres-Hernando, Barbara Philips, Boucher, Bougle, Brown, Chan, Chawla, Chung, Doi, Dowling, Dreisbach, Dreisbach, English, Fadillioglu, Gardiner, Gertz, Golab, Group, Gurley, Hassoun, Heinemeyer, Heinemeyer, Iain MacPhee, Izuwa, John Dixon, Karim, Katie Lane, Kirwan, Kirwan, Klein, Kramer, Krueger, Kunihara, Kunuzova, Lane, Lash, Leblanc, Lee, Lee, Lohr, Martyn, Mastorakos, Meier-Hellmann, Michaud, Michaud, Miyazawa, Muntane-Relat, Murakami, Naud, Naud, Nicholson, Nolin, Nolin, Okabe, Okabe, Okabe, Owen, O’Shaunessy, Park, Park, Philips, Power, Schneider, Serteser, Shi, Shibata, Smith, Soni, Spapen, Srinivas, Sun, Tanabe, Tian, Venkatesh, Wang, Whelton, Wilkinson, Wilson, Yamaguchi, Yoshitani, Yu   +82 more
core   +2 more sources

Phenotype standardization for drug-induced kidney disease. [PDF]

, 2015
Drug-induced kidney disease is a frequent cause of renal dysfunction; however, there are no standards to identify and characterize the spectrum of these disorders.
Awdishu, Linda, Cerda, Jorge, Chakaravarthi, Raj, Davenport, Andrew, Goldstein, Stuart L, Holden, Arthur L, Macedo, Etienne, Mehta, Ravindra L, Murray, Patrick T   +8 more
core   +2 more sources

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]

, 2010
Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D., Höltje, M., Korting, Hans Christian, Schäfer-Korting, Monika   +3 more
core   +1 more source

Effects of renal impairment on transporter‐mediated renal reabsorption of drugs and renal drug–drug interactions: A simulation‐based study [PDF]

Biopharmaceutics & Drug Disposition, 2018
AbstractRenal impairment (RI) significantly impacts the clearance of drugs through changes in the glomerular filtration rate, protein binding and alterations in the expression of renal drug transport proteins and hepatic metabolizing enzymes.
Kristin E. Follman, Rutwij A. Dave, Marilyn E. Morris   +2 more
openaire   +2 more sources

The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison

Renal Failure, 2019
Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in ...
Warumphon Sukkummee, Patcharin Jittisak, Piyanuch Wonganan, Supeecha Wittayalertpanya, Pajaree Chariyavilaskul, Asada Leelahavanichkul   +5 more
doaj   +1 more source

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]

, 2014
BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari, AS Yang, C Festuccia, C Zeller, CA Stidley, CJ Piyathilake, D Ma, D Matei, D Shang, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DW Shen, E Gordian, E San Jose-Eneriz, EA Braga, F Crea, F Fang, H Iwata, H Kantarjian, H Kroeger, HM Kantarjian, J Charlet, J Shia, JA Plumb, JP Issa, JP Issa, JS Kim, K Ghoshal, K Onda, K Ramachandran, K Tikoo, KY Tse, L Ding, L Rothem, MA Kane, ML Orta, NH Nabilsi, R Zhao, RH Finnell, S Fu, S Vijayaraghavalu, SB Baylin, SS Muerkoster, T Tanaka, TB Lee, VF Chekhun, X Chang, XJ Liang, Y Li, Y Oki, Y Zhang, ZG Liu   +55 more
core   +2 more sources

Organic Anion Transporter Family: Current Knowledge

Journal of Pharmacological Sciences, 2006
.: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai, Yoshikatsu Kanai, Hitoshi Endou   +2 more
doaj   +1 more source