Results 11 to 20 of about 72,813 (290)

Research Methods and New Advances in Drug–Drug Interactions Mediated by Renal Transporters

Molecules, 2023
The kidney is critical in the human body’s excretion of drugs and their metabolites. Renal transporters participate in actively secreting substances from the proximal tubular cells and reabsorbing them in the distal renal tubules.
Kexin Lin, Xiaorui Kong, Xufeng Tao, Xiaohan Zhai, Linlin Lv, Deshi Dong, Shilei Yang, Yanna Zhu   +7 more
doaj   +3 more sources

Endocrine and metabolic regulation of renal drug transporters. [PDF]

J Biochem Mol Toxicol, 2012
AbstractRenal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins.
Yacovino LL, Aleksunes LM.
europepmc   +4 more sources

Renal Tubular Drug Transporters [PDF]

Nephron Physiology, 2006
The kidney plays an important role in the elimination of numerous hydrophilic xenobiotics, including drugs, toxins, and endogenous compounds. It has developed high-capacity transport systems to prevent urinary loss of filtered nutrients, as well as electrolytes, and simultaneously to facilitate tubular secretion of a wide range of organic ions ...
Vincent, Launay-Vacher, Hassane, Izzedine, Svetlana, Karie, Jean Sébastien, Hulot, Alain, Baumelou, Gilbert, Deray   +5 more
openaire   +2 more sources

Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation

Pharmacological Research, 2023
Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous compounds and drugs across membranes, thus playing a critical role in disease susceptibility and drug response.
Anne T. Nies, Jörg König, Patrick Leuthold, Katja Damme, Stefan Winter, Mathias Haag, Satohiro Masuda, Stephan Kruck, Hannelore Daniel, Britta Spanier, Martin F. Fromm, Jens Bedke, Ken-ichi Inui, Matthias Schwab, Elke Schaeffeler   +14 more
doaj   +1 more source

The Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis

Pharmaceutics, 2023
Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact of inflammation on renal drug transporters remains to be elucidated.
Jhohann Richard de Lima Benzi, Patrícia Pereira dos Santos Melli, Geraldo Duarte, Jashvant D. Unadkat, Vera Lucia Lanchote   +4 more
doaj   +1 more source

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]

, 2016
BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc, Hagerty, David T, Hyndman, David, Iverson, Cory, Liu, Sha, Manhard, Kimberly, Miner, Jeffrey N, Nanavati, Payal, Quart, Barry, Shen, Zancong, Tan, Philip K, Terkeltaub, Robert, Yeh, Li-Tain   +12 more
core   +2 more sources

Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Pharmaceutics, 2020
Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters.
Nori J. L. Smeets, Carlijn H. C. Litjens, Jeroen J. M. W. van den Heuvel, Hedwig van Hove, Petra van den Broek, Frans G. M. Russel, Jan B. Koenderink, Saskia N. de Wildt   +7 more
doaj   +1 more source

Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source

Renal Transporter‐Mediated Drug‐Drug Interactions: Are They Clinically Relevant? [PDF]

The Journal of Clinical Pharmacology, 2016
AbstractThe kidney, through the distinct processes of passive glomerular filtration and active tubular secretion, plays an important role in the elimination of numerous endobiotics (eg, hormones, metabolites), toxins, nutrients, and drugs. Renal transport pathways mediating active tubular secretion and reabsorption in the proximal tubule are complex ...
Eve-Irene, Lepist, Adrian S, Ray
openaire   +2 more sources

Pharmacokinetics and Toxicokinetics Roles of Membrane Transporters at Kidney Level

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Transporters are large membrane proteins, which control the passage of various compounds through biological membranes. These proteins are divided into uptake and efflux transporters and play an important role in the toxicokinetics of many endobiotics and
Jéssica Veiga-Matos, Fernando Remião, Ana Motales   +2 more
doaj   +1 more source