Results 1 to 10 of about 72,813 (290)

Renal drug transporters and their significance in drug–drug interactions [PDF]

Acta Pharmaceutica Sinica B, 2016
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
doaj   +6 more sources

Contribution and expression of renal drug transporters in renal cell carcinoma [PDF]

Frontiers in Pharmacology
Renal cell carcinoma (RCC) is a common substantive tumor. According to incomplete statistics, RCC incidence accounts for approximately 90% of renal malignant tumors, and is the second most prevalent major malignant tumor in the genitourinary system ...
Yawen Zuo, Tong Li, Shilei Yang, Xuyang Chen, Xufeng Tao, Deshi Dong, Fang Liu, Yanna Zhu   +7 more
doaj   +6 more sources

Impact of Viral Inflammation on the Expression of Renal Drug Transporters in Pregnant Rats [PDF]

Pharmaceutics, 2019
Inflammation impacts the expression and function of drug transporters at term-gestation; however, the impact of inflammation on the expression of drug transporters at mid-gestation is largely unknown.
Navaz Karimian Pour, Eliza R. McColl, Micheline Piquette-Miller   +2 more
doaj   +4 more sources

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells [PDF]

Pharmaceutics
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes.
Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J. Kelly, Jashvant D. Unadkat   +4 more
doaj   +4 more sources

The System Profile of Renal Drug Transporters in Tubulointerstitial Fibrosis Model and Consequent Effect on Pharmacokinetics [PDF]

Molecules, 2022
With the widespread clinical use of drug combinations, the incidence of drug–drug interactions (DDI) has significantly increased, accompanied by a variety of adverse reactions.
Birui Shi, Yan Zhang, Baolin Huang, Huiping Lin, Qiong Zhou, Yujue Wang, Zheng Cai, Menghua Liu   +7 more
doaj   +2 more sources

Entecavir interacts with influx transporters hOAT1, hCNT2, hCNT3, but not with hOCT2: the potential for renal transporter-mediated cytotoxicity and drug-drug interactions

Frontiers in Pharmacology, 2016
Entecavir (ETV) is one of the most potent agents for the treatment of the hepatitis B viral infection. The drug is principally eliminated by the kidney.
František eTrejtnar, Jana eMandíková, Marie eVolková, Petr ePávek, Lucie eNavrátilová, Lucie eHyršová, Zlatko eJaneba, Jan ePavlík, Pavel eBárta   +8 more
doaj   +3 more sources

Membrane Carriers and Transporters in Kidney Physiology and Disease

Biomedicines, 2021
The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as ...
Marek Drozdzik, Maria Drozdzik, Stefan Oswald   +2 more
doaj   +1 more source

A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Pharmaceutics, 2021
Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang, Zexin Zhang, Ping Li, Weimin Kong, Xiaodong Liu, Li Liu   +5 more
doaj   +1 more source

Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking

Frontiers in Pharmacology, 2021
The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process.
Wei Zou, Birui Shi, Ting Zeng, Yan Zhang, Baolin Huang, Bo Ouyang, Zheng Cai, Zheng Cai, Menghua Liu, Menghua Liu   +9 more
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Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid

Pharmaceutics, 2021
We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier ...
Yun Ju Kang, Chul Haeng Lee, Soo-Jin Park, Hye Suk Lee, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source